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ProteomicsOrganophosphorus pesticides catalyze protein crosslinking
Exposure to organophosphorus pesticides (OP) can have chronic adverse effects that are independent of inhibition of acetylcholinesterase, the classic target for acute OP toxicity. In pure proteins, the organophosphorus pesticide chlorpyrifos oxon induces a crosslink between lysine and glutamate (or...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2022-10-14 | PXD034529 | Pride
Chlorpyrifos oxon Protein prospector Map-rich tubulin Isopeptide Crosslinks 
ProteomicsEvaluation of mass spectrometry MS/MS spectra for the presence of isopeptide crosslinked peptides
Isopeptide crosslinked proteins can be the product of transglutaminase or of exposure to organophosphorus toxicants (OP). Transglutaminase links glutamine to lysine with loss of ammonia. OP toxicants induce a link between glutamic acid and lysine with loss of water. Our goal was to establish crit...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2021-07-12 | PXD026790 | Pride
Transglutaminase Dansyl cadaverine Isopeptide Dansyl-aminohexyl qqiv Protein prospector Map-rich tubulin Neurodegenerative disease Crosslinks 
ProteomicsPRR of Tau Crosslinking with Tubulin
We used cross-linking mass spectrometry with the cleavable cross-linker, disuccinimidyl dibutyric urea (DSBU) to map sites of interaction between the proline rich domain (PRR, tau amino acids 149-244) and tubulin. For comparison, we also conducted these experiments with PRR constructs containing mul...
ORGANISM(S): Bos taurus (Bovine) Escherichia coli 
2026-03-09 | PXD049384 | Pride
Tubulin Tau Phosphorylation Proline rich region 
ProteomicsStructural Insights into the Role of the Proline Rich Region in Tau Function
Tau is a microtubule-associated protein that plays an important role in modulating axonal microtubules in neurons. Intracellular tau aggregates are found in a broad class of disorders, including Alzheimer’s disease, termed tauopathies. Tau is an intrinsically disordered protein, and its structural d...
ORGANISM(S): Escherichia coli 
2025-01-31 | PXD059518 | Pride
Post-translational modifications Alzheimer's disease Tubulin Tau Phosphorylation Microtubules Aggregation 
UnknownA direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylation.
Not available
S-EPMC3887213 | biostudies-literature
UnknownRole of Phosphorylation and Hyperphosphorylation of Tau in Its Interaction with βα Dimeric Tubulin Studied from a Bioinformatics Perspective.
Not available
S-EPMC7903436 | biostudies-literature
UnknownEvaluation of mass spectrometry MS/MS spectra for the presence of isopeptide crosslinked peptides.
Not available
S-EPMC8270460 | biostudies-literature
ProteomicsEvaluation of mass spectrometry MS/MS spectra for the presence of isopeptide crosslinked peptides
Chronic low dose exposure to organophosphorus pesticides is associated with risk of neurodegenerative disease. The mechanism of neurotoxicity is unknown, though it is independent of acetylcholinesterase inhibition. Adducts on tyrosine, lysine, threonine, and serine can occur after exposure to organo...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-02-17 | PXD027203 | Pride
Transglutaminase Dansyl cadaverine Isopeptide Dansyl-aminohexyl qqiv Protein prospector Map-rich tubulin Neurodegenerative disease Crosslinks 
TranscriptomicsIntegrated analysis reveals effects of bioactive ingredients from Limonium Sinense (Girard) Kuntze on hypoxia-inducible factor (HIF) activation
Limonium Sinense (Girard) Kuntze is a traditional Chinese medicinal herb, showing blood replenishment, anti-tumour, anti-hepatitis, and immunomodulation activities amongst others. However, the mechanism of its pharmacological activities remains largely unknown. Here, we investigated the effects of b...
ORGANISM(S): Homo sapiens 
2022-09-29 | GSE205252 | GEO
UnknownOrganophosphorus Pesticides Promote Protein Cross-Linking.
Not available
S-EPMC9490787 | biostudies-literature
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