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ProteomicsProteome of naive and TCR activated wild-type, Myc-deficient and Slc7a5-deficient T cells
T cell clonal expansion and differentiation are critically dependent on the transcription factor c-Myc (Myc). Herein we use quantitative mass-spectrometry to reveal how Myc controls antigen receptor driven cell growth and proteome restructuring in CD4+ and CD8+ T cells. Quantitative proteomics was p...
ORGANISM(S): Mus musculus (Mouse) 
2020-02-25 | PXD016105 | Pride
Lc-msms Mouse T lymphocyte Myc Slc7a5 Amino acid transport 
ProteomicsOT1 T cell activation time course
Time course of OT1 T cell activation with SIINFEKL peptide.
ORGANISM(S): Mus musculus (Mouse) 
2020-02-25 | PXD016443 | Pride
T cell activation Mouse T lymphocyte 
ProteomicsProteome of WT and Usp30KO cytotoxic T lymphocytes
Recent work in immunometabolism has emphasised the role of mitochondria in both the innate and adaptive immune system. Mitochondria are important in T cell development and differentiation, but less is known about their role in CD8+ effector T cells (CTLs). We found that CTLs that lack the mitochondr...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-09 | PXD021508 | Pride
Lc-msms Usp30 Dia Mouse T lymphocyte 
ProteomicsDoxycycline treated cytotoxic T lymphocytes
Recent work in immunometabolism has emphasised the role of mitochondria in both the innate and adaptive immune system. Mitochondria are important in T cell development and differentiation, but less is known about their role in CD8+ effector T cells (CTLs). We found that CTLs that lack the mitochondr...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-09 | PXD026948 | Pride
T cell Dia Mouse Ctl Protein translation Doxycycline Mitochondria 
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