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GenomicsGenome wide uH2A localization analysis highlights Bmi1-dependent deposition of the mark at repressed genes.
Polycomb group (PcG) proteins control organism development by regulating the expression of developmental genes. Transcriptional regulation by PcG proteins is achieved at least partly through the PRC2-mediated methylation on lysine 27 of histone H3 (H3K27) and PRC1-mediated ubiquitylation on lysine 1...
ORGANISM(S): Mus musculus 
2009-05-20 | E-GEOD-15896 | biostudies-arrayexpress
GenomicsLarge-scale methylation domains mark a functional subset of neuronally expressed genes
DNA methylation is essential for embryonic and neuronal differentiation, but the function of most genomic DNA methylation marks are poorly understood. Generally the human genome is highly methylated (>70%) except for CpG islands and gene promoters. However, it was recently shown that the IMR90 human...
ORGANISM(S): Homo sapiens 
2011-06-23 | E-GEOD-25930 | biostudies-arrayexpress
TranscriptomicsAn epigenetic mark of polycomb response elements implemented by Trx/MLL/COMPASS
In Drosophila, Polycomb Response Elements (PREs) are identified as genomic sequences allowing the maintenance of transcriptional repression in the absence of the initiating signal. Although PREs in Drosophila are well characterized, the existence of mammalian PRE-like elements remains debated. Accu...
ORGANISM(S): Homo sapiens 
2016-07-26 | E-GEOD-81795 | biostudies-arrayexpress
TranscriptomicsRepressive and active histone methylation mark distinct promoters in human and mouse spermatozoa
This SuperSeries is composed of the following subset Series: GSE13863: Repressive and active histone methylation mark distinct promoters in human and mouse spermatozoa (Nimblegen) GSE19889: Repressive and active histone methylation mark distinct promoters in human and mouse spermatozoa (Illumina) Re...
ORGANISM(S): Homo sapiens 
2010-05-16 | E-GEOD-19892 | biostudies-arrayexpress
GenomicsRepressive and active histone methylation mark distinct promoters in human and mouse spermatozoa (Illumina)
In higher eukaryotes, histone methylation is involved in the maintenance of cellular identity during somatic development. During spermatogenesis, Since most nucleosomes are replaced by protamines during spermatogenesis . Iit is therefore unclear whether if histone modifications function in paternal ...
ORGANISM(S): Homo sapiens 
2010-05-16 | E-GEOD-19889 | biostudies-arrayexpress
GenomicsCucumis melo cultivar:Top Mark
Cucumis melo cultivar:Top Mark Raw sequence reads
PRJNA358651 | ENA
GenomicsCucumis melo cultivar:Top Mark
Cucumis melo cultivar:Top Mark Raw sequence reads
PRJNA358648 | ENA
GenomicsCucumis melo cultivar:Top Mark
Cucumis melo cultivar:Top Mark Raw sequence reads
PRJNA358674 | ENA
GenomicsCytosine methylation and hydroxymethylation mark DNA for elimination in Oxytricha trifallax.
We report the existence of both methylcytosine and hydroxymethylcytosine in the genomic DNA of the ciliate Oxytricha trifallax during its genome rearrangement process. These modifications are dynamically added, de novo, to sequences targeted for elimination and are not present after the rearrangemen...
ORGANISM(S): Oxytricha trifallax 
2012-09-26 | E-GEOD-41060 | biostudies-arrayexpress
ProteomicsLysine benzoylation - Here we report the identification and characterization of a histone mark, lysine benzoylation (Kbz). Our study identifies 22 Kbz sites on histones from HepG2 and RAW cells. This type of histone mark can be stimulated by sodium benzoate (SB), a FDA-approved drug and a widely used chemical food preservative, via generation of benzoyl CoA.
Here we report the identification and characterization of a histone mark, lysine benzoylation (Kbz). Our study identifies 22 Kbz sites on histones from HepG2 and RAW cells. This type of histone mark can be stimulated by sodium benzoate (SB), a FDA-approved drug and a widely used chemical food preser...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2018-07-11 | PXD010332 | Pride
Ptm Benzoylation Histone mark 
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