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ProteomicsLysine benzoylation - Here we report the identification and characterization of a histone mark, lysine benzoylation (Kbz). Our study identifies 22 Kbz sites on histones from HepG2 and RAW cells. This type of histone mark can be stimulated by sodium benzoate (SB), a FDA-approved drug and a widely used chemical food preservative, via generation of benzoyl CoA.
Here we report the identification and characterization of a histone mark, lysine benzoylation (Kbz). Our study identifies 22 Kbz sites on histones from HepG2 and RAW cells. This type of histone mark can be stimulated by sodium benzoate (SB), a FDA-approved drug and a widely used chemical food preser...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2018-07-11 | PXD010332 | Pride
Ptm Benzoylation Histone mark 
GenomicsLysine benzoylation is a novel histone mark [RNA-seq]
Lysine benzoylation is a novel histone mark [RNA-seq]
PRJNA427337 | ENA
GenomicsLysine benzoylation is a novel histone mark [ChIP-seq]
Lysine benzoylation is a novel histone mark [ChIP-seq]
PRJNA427338 | ENA
ProteomicsHBO1 Catalyzes Lysine Benzoylation in Mammalian Cells
Lysine benzoylation (Kbz) is a newly discovered protein post-translational modification (PTM). This PTM can be stimulated by benzoate and contributes to gene expression. However, its regulatory enzymes and substrate proteins remain largely unknown, hindering further functional studies. Here we ident...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD034187 | Pride
Lysine benzoylation Post-translational modification Hbo1 Transferase 
ProteomicsLC-MS/MS identification of Kbz sites on histones catalyzed by non-enzymatic and enzymatic ways.
Histone lysine benzoylation may occur by Gcn5-catalyzed and nonenzymatically ways in vivo. In this project, we identified several Kbz sites on Xenopus laevis octamer in the absence or presence Gcn5-Ada2 complex in vitro, respectively. The number 672 represents the data in the absence of Gcn5-Ada2, a...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-05-19 | PXD030110 | Pride
Lc-ms/ms Nonenzymatically S. cerevisiae Benzoylation Gcn5-ada2 Xenopus laevis octamer 
ProteomicsGlobal profiling of lysine benzoylation in S. cerevisiae
Identification of 207 Kbz sites on 149 non-histone proteins by LC-MS/MS
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-05-20 | PXD029997 | Pride
Proteome-wide screening Lc-ms/ms S. cerevisiae Lysine benzoylation Non-histone 
TranscriptomicsLysine benzoylation is a novel histone mark [RNA-seq]
We identified and characterized a previously undescribed histone mark, lysine benzoylation. This histone mark could be modulated by sodium benzoate (SB), an FDA-approved drug and a widely used chemical food preservative, via generation of benzoyl CoA. By ChIP-seq and RNA-seq analysis, we demonstrate...
ORGANISM(S): Homo sapiens 
2018-06-08 | GSE108469 | GEO
GenomicsLysine benzoylation is a novel histone mark [ChIP-seq]
We identified and characterized a previously undescribed histone mark, lysine benzoylation. This histone mark could be modulated by sodium benzoate (SB), an FDA-approved drug and a widely used chemical food preservative, via generation of benzoyl CoA. By ChIP-seq and RNA-seq analysis, we demonstrate...
ORGANISM(S): Homo sapiens 
2018-06-08 | GSE108468 | GEO
UnknownRegioselective Benzoylation of Diols and Carbohydrates by Catalytic Amounts of Organobase.
Not available
S-EPMC6274181 | biostudies-literature
GenomicsLysine benzoylation is a novel histone mark
Lysine benzoylation is a novel histone mark
PRJNA427334 | ENA
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