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Histone lysine benzoylation may occur by Gcn5-catalyzed and nonenzymatically ways in vivo. In this project, we identified several Kbz sites on Xenopus laevis octamer in the absence or presence Gcn5-Ada2 complex in vitro, respectively. The number 672 represents the data in the absence of Gcn5-Ada2, a...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-05-19 | PXD030110 | Pride
Endoplasmic-reticulum resident inositol-requiring enzyme 1a (IRE1) supports protein homeostasis via its cytoplasmic kinase-RNase module. Known cancer dependency on IRE1 entails its enzymatic activation of the transcription factor XBP1s and of regulated RNA decay. We discovered that some cancer cells...
ORGANISM(S): Homo sapiens 
2025-01-07 | GSE285981 | GEO
Together with other post-translational modifications, acylation of proteins is a powerful means of regulation of their activity. Some acylation types occur nonenzymatically and are driven by an increase in the concentration of acyl group donors. Lysine succinylation has a profound effect on the corr...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-10-26 | PXD023604 | Pride
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