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GenomicsH2A.Z marks antisense promoters and has positive effects on antisense transcript levels in budding yeast
The histone variant H2A.Z, which has been reported to have both activating and repressive effects on gene expression, is known to occupy nucleosomes at the 5’ ends of protein-coding genes. We now find that H2A.Z is also significantly enriched in gene coding regions and at the 3’ ends of genes in bud...
ORGANISM(S): Saccharomyces cerevisiae 
2015-01-05 | E-GEOD-54105 | biostudies-arrayexpress
ProteomicsJASPer controls interphase histone H3S10 phosphorylation by chromosomal kinase JIL-1 in Drosophila
In Drosophila the chromosomal kinase JIL-1 is responsible for most interphase histone H3S10 phosphorylation and has been proposed to protect active chromatin from acquiring heterochromatic marks, like dimethylated histone H3K9 (H3K9me2) and HP1. Here, we show that JIL-1’s targeting to chromatin depe...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2019-10-09 | PXD012790 | Pride
Jil-1 Pwwp Compass Chromatin B-jim Set1 H3s10ph Dpy30-l1 H3k36me3 Bod1 
UnknownHypoxia Induces Production of L-2-Hydroxyglutarate.
Not available
S-EPMC4527873 | biostudies-literature
UnknownSpecific expression of novel long non-coding RNAs in high-hyperdiploid childhood acute lymphoblastic leukemia.
Not available
S-EPMC5367703 | biostudies-literature
UnknownMutant-IDH1-dependent chromatin state reprogramming, reversibility, and persistence.
Not available
S-EPMC5769471 | biostudies-literature
ProteomicstRNA Biogenesis and Specific Aminoacyl-tRNA Synthetases Regulate Senescence Stability Under the Control of mTOR
Oncogenes or chemotherapy treatments trigger the induction of suppressive pathways such as apoptosis or senescence. Senescence was initially defined as a definitive arrest of cell proliferation but recent results have shown that this mechanism is also associated with cancer progression and chemother...
ORGANISM(S): Homo sapiens (Human) 
2021-12-09 | PXD029535 | Pride
Chemotherapy Trna Er stress Senescence P21 Mtor 
UnknownSirtuin 2 inhibition modulates chromatin landscapes genome-wide to induce senescence in ATRX-deficient malignant glioma.
Not available
S-EPMC10769000 | biostudies-literature
UnknownPre-surgical trial of the AKT inhibitor MK-2206 in patients with operable invasive breast cancer: a New York Cancer Consortium trial.
Not available
S-EPMC6222014 | biostudies-literature
UnknownPharmacokinetics of high-dose lopinavir-ritonavir with and without saquinavir or nonnucleoside reverse transcriptase inhibitors in human immunodeficiency virus-infected pediatric and adolescent patients previously treated with protease inhibitors.
Not available
S-EPMC2533475 | biostudies-literature
GenomicsDNA Methylation Analysis of Prostate Cancer Cell Lines and Tissues Using Next Generation Sequencing

Aberrant DNA methylation changes are known to occur during prostate cancer progression beginning with precursor lesions. Utilizing fifty nanograms of genomic DNA in Methylplex-Next Generation Sequencing (M-NGS) we mapped the global DNA methylation patterns in prostate tissues (n=17) and cells (n=...

phs000597.v1.p1 | EGA
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