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TranscriptomicsLgr6 Marks Stem Cells in the Hair Follicle that Generate all Cell Lineages of the Skin
Mammalian epidermis consists of three self-renewing compartments: the hair follicle, sebaceous gland and interfollicular epidermis. We generated knock-in alleles of murine Lgr6, a close relative to the Lgr5 stem cell gene. Lgr6 was expressed in the earliest embryonic hair placodes. In adult hair fol...
ORGANISM(S): Mus musculus 
2010-03-25 | E-GEOD-20269 | biostudies-arrayexpress
TranscriptomicsHistone H2A.Z and DNA methylation are mutually antagonistic chromatin marks
Eukaryotic chromatin is separated into functional domains differentiated by posttranslational histone modifications, histone variants, and DNA methylation. Methylation is associated with repression of transcriptional initiation in plants and animals, and is frequently found in transposable elements...
ORGANISM(S): Arabidopsis thaliana 
2008-10-02 | E-GEOD-12212 | biostudies-arrayexpress
ProteomicsZc3h13/Flacc is required for adenosine methylation by bridging the mRNA binding factor Rbm15/Spenito to other components of the m6A machinery
N6-methyladenosine (m6A) is an abundant RNA modification in eukaryotes, playing crucial roles in multiple biological processes. m6A is catalyzed by the activity of Mettl3, which depends on additional proteins whose precise functions remain poorly understood. Here we identified Flacc/Zc3h13 as a nove...
ORGANISM(S): Mus musculus (Mouse) Drosophila melanogaster (Fruit fly) 
2018-12-20 | PXD008111 | Pride
Rna modifications Flacc Methyltransferase complex M6a Sex determination Zc3h13 
TranscriptomicsChIPseq for histone marks in WT and Hdac3 knock-out clones of TNG-A derived mESCs in 2iLIF and SL differentiation conditions
H3K27ac and H4K5ac ChIPseq in WT and Hdac3-/- mESCs in order to determine the role of Hdac3 on the activity of cis-regulatory elements during differentiation.
This experiment is part of the study: "Mechanistic framework of lineage restriction in embryonic stem cells" by Olivieri et al.
ORGANISM(S): Mus musculus 
2021-03-15 | E-MTAB-9450 | biostudies-arrayexpress
UnknownRandomized, double-blind, placebo-controlled, phase III chemoprevention trial of selenium supplementation in patients with resected stage I non-small-cell lung cancer: ECOG 5597.
Not available
S-EPMC3821010 | biostudies-literature
GenomicsGenome-wide analysis of H3.3 dissociation in mouse embryonic stem cells
Using Tet-inhibited expression of epitope-tagged H3.3 combined with ChIP-Seq we undertook genome-wide measurements of H3.3 dissociation rates across the ESC genome and examined the relationship between H3.3-nucleosome turnover and ESC-specific transcription factors, chromatin modifiers and epigeneti...
ORGANISM(S): Mus musculus 
2015-05-14 | E-GEOD-63641 | biostudies-arrayexpress
GenomicsGenome-wide incorporation dynamics reveal distinct categories of turnover for the histone variant H3.3
We developed a system to study the DNA replication-independent turnover nucleosomes containing the histone variant H3.3 in mammalian cells. By measuring the genome-wide incorporation of H3.3 at different time points following epitope-tagged H3.3 expression, we find three categories of H3.3-nucleosom...
ORGANISM(S): Mus musculus 
2013-10-23 | E-GEOD-51505 | biostudies-arrayexpress
TranscriptomicsRegulation of the microRNA processor DGCR8 by the tumor suppressor ING1
The ING familiy of tumor suppressor proteins control several cellular functions relevant to anti-tumor protection, like cell-cycle control, apoptosis, senescence or migration. ING proteins are functionally linked to the p53 pathway, and they participate in transcriptional control via the recognisit...
ORGANISM(S): Homo sapiens 
2010-06-20 | E-GEOD-18645 | biostudies-arrayexpress
GenomicsGenome-wide profiling of the meiotic recombinase DMC1, the chromosome axis protein ASY1 and chromatin states in hexaploid wheat (ChIP-seq)
We performed ChIP-seq for the meiotic strand exchange protein DMC1, which marks an early stage in the meiotic recombination pathway, and the chromosome axis protein ASY1, which promotes interhomolog synapsis and recombination in plants, using tissue collected from immature pre-emergence spikes from ...
ORGANISM(S): Triticum aestivum 
2021-07-07 | E-MTAB-9632 | biostudies-arrayexpress
ProteomicsA chemoproteomic portrait of the oncometabolite fumarate
Hereditary cancer disorders often provide an important window into novel mechanisms supporting tumor growth and survival. Understanding these mechanisms and developing biomarkers to identify their presence thus represents a vital goal. Towards this goal, here we report a chemoproteomic map of the co...
ORGANISM(S): Homo sapiens (Human) 
2018-11-27 | PXD009378 | Pride
Lc-msms Uok262 Fumarate Hereditary leiomyomatosis and renal cell carcinoma (hlrcc) Succination Fumarate hydratase (fh) Cysteine reactivity 
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