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MetabolomicsGut Microbiome Composition Is Associated With Future Onset of Crohn's Disease in Healthy First-Degree Relatives.

BACKGROUND & AIMS: The cause of Crohn's disease (CD) is unknown, but the current hypothesis is that microbial or environmental factors induce gut inflammation in genetically susceptible individuals, leading to chronic intestinal inflammation. Case-control studies of patients...

2023-11-16 | MTBLS300 | MetaboLights
ProteomicsDepletion of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication
New therapeutic targets are a valuable resource in the struggle to reduce the morbidity and mortality associated with the COVID-19 pandemic. Genome-wide association studies (GWAS) have identified a number of risk loci but these include co-morbidities and are not specific to host-virus interactions. ...
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD031611 | Pride
Sars-cov-2 Viral replication Exosc2 
ProteomicsProteomics and phosphoproteomics of medicinal cannabis plant extract (NTI164) treatment of paediatric acute-onset neuropsychiatric syndrome
Paediatric acute-onset neuropsychiatric Syndrome (PANS) is a syndrome of infection-provoked abrupt-onset obsessive-compulsive disorder (OCD) or eating restriction. This open-label trial investigated the safety and efficacy of NTI164, a cannabis-derived medicinal formulation rich in cannabinoids (min...
ORGANISM(S): Homo sapiens (Human) 
2026-03-16 | PXD064184 | Pride
Epigenetics Multi-omics Qe plus Immune Tmt Ribosome Cannabis Pans Translation 
ProteomicsProteomic and phosphoproteomics analysis of triple combination therapy in cystic fibrosis
Trikafta, a CFTR modulator, is increasingly used to treat children with cystic fibrosis (CF), but its effects remain unclear. This study evaluated the cellular mechanisms of Trikafta in young children (< 11 years) with CF using a multi-omic approach. Seventeen children with CF (median age 8.4 years,...
ORGANISM(S): Homo sapiens (Human) 
2026-08-03 | PXD060637 | Pride
Therapeutics Drug Cystic fibrosis Phosphorylation 
ProteomicsProteome analysis of cumulative antenatal and postnatal environmental exposure in the brain of mice
Environmental exposures across critical developmental windows can significantly influence brain development and contribute to the risk of neurodevelopmental disorders (NDDs). Importantly, emerging clinical evidence suggests that multiple environmental factors during early development result in more ...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-19 | PXD060752 | Pride
C57bl/6 Brain Neurodevelopmental disorder Development Environmental exposure 
TranscriptomicsPriming defense genes and metabolites in hybrid poplar by the green leaf volatile cis-3-hexenyl acetate
• Herbivore-induced plant volatiles (HIPVs), in addition to attracting natural enemies of herbivores, can serve a signaling function within plants by acting as wound signals that induce or prime defenses. However, particularly in woody plants, which compounds within HIPV blends are capable of act...
ORGANISM(S): Populus x canadensis 
2010-05-25 | E-GEOD-11955 | biostudies-arrayexpress
ProteomicsNeuroblastoma HLA class I Immunopeptidomics
We surveyed the immunopeptidome of neuroblastoma tumors to identify tumor-specific targets derived from non-mutated self proteins originating from core-regulatory circuit proteins.
ORGANISM(S): Homo sapiens (Human) 
2021-08-11 | PXD027182 | Pride
Tumor antigens Neuroblastoma immunopeptidomics Hla class i Phox2b 
Transcriptomics21 Breast Cancer Genome Affymetrix SNP6 Array Data
Cancer evolves dynamically, as clonal expansions supersede or overlap one another, driven by shifting selective pressures, mutational processes and disrupted cancer genes. These processes mark the genome, such that a cancerÕs life history is encrypted in the timing, ploidy, clonality and patterns of...
ORGANISM(S): Homo sapiens 
2012-06-16 | E-MTAB-1087 | biostudies-arrayexpress
UnknownGenome-wide association analysis of hippocampal volume identifies enrichment of neurogenesis-related pathways.
Not available
S-EPMC6787090 | biostudies-literature
UnknownIn vitro and in vivo drug screens of tumor cells identify novel therapies for high-risk child cancer
Not available
S-SCDT-EMM-2021-14608 | biostudies-other
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