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ProteomicsSerine ADP-ribosylation depends on HPF1
We report that serine ADPr is strictly dependent on HPF1 (histone PARylation factor 1. Quantitative proteomics revealed that serine ADPr does not occur in cells lacking HPF1. We identified three endogenous serine ADPr sites are located on the PARP-1 automodification domain. Further identification of...
ORGANISM(S): Homo sapiens (Human) 
2017-02-10 | PXD005627 | Pride
Adp-ribosylation  hpf1  parp-1  parp-2  histones  proteomics 
ProteomicsHistone ADP Ribosylation - Serine is a new target residue for endogenous ADP-ribosylation on histones
ADPr sites on histones obtained from cells were directly identified. We have identified 12 unique ADPr sites in human osteosarcoma cells and report serine ADPr as a new type of histone mark that responds to DNA damage.
ORGANISM(S): Homo sapiens (Human) Gallus gallus (Chicken) 
2016-12-22 | PXD005462 | Pride
Adpr Histones Serine Adp ribosylation 
ProteomicsAn HPF1/PARP1-based chemical biology strategy for exploring ADP-ribosylation
Strategies for installing authentic ADP-ribosylation (ADPr) at desired positions are fundamental for creating the tools needed to explore this elusive PTM in essential cellular processes. Here we describe a phospho-guided chemoenzymatic approach based on the Ser-ADPr writer complex for rapid, scalab...
ORGANISM(S): Homo sapiens (Human) 
2020-11-17 | PXD020589 | Pride
Parp1 Lc-ms Fusion Adp-ribosylation 
ProteomicsIdentification of mono-ADPr readers by multilevel chromatin proteomics
We performed multilevel proteomics to identify mono-ADPr readers. Pulldowns using ADPribosylated peptides and nucleosomes, analysis of the chromatin proteome using targeted modulations of the ADPr system (H2O2 treatment, ARH3 KO, HPF1 KO). We reveal multiple mono-ADPr readers, including RNF114, a ...
ORGANISM(S): Homo sapiens (Human) 
2023-04-28 | PXD037026 | Pride
Adpribosylation Histone marks Human Ptm Mono-adpr Chromatin Lc-ms/ms 
ProteomicsMass-Spectrometric analysis of SdeA Ubiquitin modification and Ubiquitination
Conventional ubiquitination involves the ATP-dependent formation of amide bonds between the ubiquitin C-terminus and primary amines in substrate proteins. Recently, SdeA, an effector protein of pathogenic Legionella pneumophila, was shown to mediate NAD-dependent and ATP-independent ubiquitin transf...
ORGANISM(S): Homo sapiens (Human) 
2016-12-07 | PXD005240 | Pride
Legionella pneumophila Etd Orbitrap fusion 
ProteomicsProteome-wide identification of SUMO2 modification sites
Posttranslational modification with small ubiquitin-like modifiers (SUMOs) alters the function of proteins involved in diverse cellular processes. SUMOs are conjugated to lysine residues in target proteins by SUMO-specific enzymes. Although proteomic studies have identified hundreds of sumoylated su...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080741 | MassIVE
ProteomicsH.sapiens - Cell line, U2os (Lundberg,msb,2010)
abundance based on MAPPED_BY_AUTHORS, U2OS, Interaction consistency score: 15.2, Coverage: 27
ORGANISM(S): 9606 
2010-00-00 | 3087941123 | PAXDB
ProteomicsH.sapiens - Cell line, A431 (Lundberg,msb,2010)
abundance based on MAPPED_BY_AUTHORS, A431, Interaction consistency score: 15.1, Coverage: 27
ORGANISM(S): 9606 
2010-00-00 | 986013392 | PAXDB
ProteomicsH.sapiens - Cell line, U251mg (Lundberg,msb,2010)
abundance based on MAPPED_BY_AUTHORS, U251MG, Interaction consistency score: 15.0, Coverage: 27
ORGANISM(S): 9606 
2010-00-00 | 2206792627 | PAXDB
UnknownHeart failure in Europe: Guideline-directed medical therapy use and decision making in chronic and acute, pre-existing and de novo, heart failure with reduced, mildly reduced, and preserved ejection fraction - the ESC EORP Heart Failure III Registry.
Not available
S-EPMC11683873 | biostudies-literature
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