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MetabolomicsDetermination of Abundant Metabolite Matrix Adducts Illuminates the Dark Metabolome of MALDI-Mass Spectrometry Imaging Datasets
Spatial metabolomics using mass spectrometry imaging (MSI) is a powerful tool to map hundreds to thousands of metabolites in biological systems. One major challenge in MSI is the annotation of m/z values, which is substantially complicated by background ions introduced throughout the c...
2021-06-15 | MTBLS954 | MetaboLights
TranscriptomicsNuclear Matrix Association in Proliferative and Invasive Cytotrophoblasts
Abnormal trophoblast invasion is associated with the most common and most severe complications of human pregnancy. The biology of invasion, as well as the etiology of abnormal invasion remains poorly understood. The aim of this study was to characterize the transcriptome of the HTR-8/SVneo human c...
ORGANISM(S): Homo sapiens 
2010-06-22 | E-GEOD-17501 | biostudies-arrayexpress
TranscriptomicsNuclear scaffold and matrix attachment of HeLa chromatin
The nuclear scaffold/matrix provides an anchor for higher order genome structure that has both structural and functional implications. Different extraction protocols, i.e., utilizing either 25 mM LIS or 2 M NaCl, isolate somewhat different protein constituents of either the nuclear scaffold or nucl...
ORGANISM(S): Homo sapiens 
2010-05-22 | E-GEOD-13774 | biostudies-arrayexpress
TranscriptomicsNuclear scaffold and matrix attachment of Aortic Adventitial Fibroblast (AoAF) chromatin
The nuclear scaffold/matrix provides an anchor for higher order genome structure that has both structural and functional implications. Different extraction protocols, i.e., utilizing either 25 mM LIS or 2 M NaCl, isolate somewhat different protein constituents of either the nuclear scaffold or nucl...
ORGANISM(S): Homo sapiens 
2009-03-10 | E-GEOD-13792 | biostudies-arrayexpress
ProteomicsInvestigating the effect of fluid flow on glomerular cell-derived matrix
The glomerular basement membrane has a complex composition and structure in vivo. In vitro models of the glomerular capillary wall have been developed using microfluidic and perfusion systems, however, how the extracellular matrix alters under static and flow conditions has not yet been investigate...
ORGANISM(S): Homo sapiens (Human) 
2026-02-02 | PXD044226 | Pride
Glomerular matrix Microfluidic bioreactor Glomerular filtration barrier 
ProteomicsHydroxylamine Chemical Digestion for Insoluble Extracellular Matrix Characterization
The extracellular matrix (ECM) is readily enriched by decellularizing tissues with non-denaturing detergents to solubilize and deplete the vast majority of cellular components. This approach has been used extensively to generate ECM scaffolds for regenerative medicine technologies and in 3D cell cul...
ORGANISM(S): Mus musculus (Mouse) 
2017-10-20 | PXD006428 | Pride
Proteomics Mass spectrometry Lc-srm Matrisome Tissue extraction Collagen Chemical digestion Extracellular matrix 
TranscriptomicsNon-Replicating Mycobacterium tuberculosis Elicits a Reduced Infectivity Profile with Corresponding Modifications to the Cell Wall and Extracellular Matrix
A key feature of Mycobacterium tuberculosis is its ability to become dormant in the host. Little is known of the mechanisms by which these bacilli are able to persist in this state. Therefore, the focus of this study was to emulate environmental conditions encountered by M. tuberculosis in the granu...
ORGANISM(S): Mycobacterium tuberculosis 
2016-11-14 | E-BUGS-142 | biostudies-arrayexpress
ProteomicsProteomic profiling of human left ventricular extracellular matrix
Proteomic analysis of decellularized human left ventricular extracellular matrix used for engineering humanized heart tissues. Data were generated to characterize ECM composition supporting cardiotoxicity assessment in a recellularized engineered heart tissue platform.
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD074354 | Pride
Heart Ventricular Extracellular matrix 
MetabolomicsSingle-cell lipidomic analysis of the Epithelial-Mesenchymal Transition (EMT) using MALDI-MSI

EMT is a metastasis-promoting process whose heterogeneity has been extensively studied at a gene expression level. EMT also involves reprogramming of lipid metabolism, however there has been little focus on heterogeneity on the lipid level. Here, we use MALDI-MSI to determine the levels of variou...

2026-04-15 | MTBLS12650 | MetaboLights
ProteomicsThe Adult Aedes aegypti Midgut Peritrophic Matrix Proteome
This study was undertaken to characterize the proteome of the midgut peritrophic matrix of Aedes aegypti.
ORGANISM(S): Aedes aegypti aegypti 
2018-04-05 | PXD007627 | Pride
Midgut Peritrophic matrix A. aegypti 
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