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Proteomics15 cm Aurora Gen3 column benchmarking on an Exploris 480
A comprehensive proteome map is essential to elucidate molecular pathways and protein functions. Although great improvements in sample preparation, instrumentation and data analysis already yield-ed impressive results, current studies suffer from a limited proteomic depth and dynamic range there-for...
ORGANISM(S): Homo sapiens (Human) 
2024-02-13 | PXD045457 | Pride
Vanquish neo Orbitrap exploris 480 Trap-and-elute 
ProteomicsBenchmarking of 5.5 cm, 50 cm and 110 cm micropillar array columns as compared to packed bed columns
A comprehensive proteome map is essential to elucidate molecular pathways and protein functions. Although great improvements in sample preparation, instrumentation and data analysis already yield-ed impressive results, current studies suffer from a limited proteomic depth and dynamic range there-for...
ORGANISM(S): Homo sapiens (Human) Escherichia coli Saccharomyces cerevisiae (Baker's yeast) 
2024-02-13 | PXD039576 | Pride
E. coli Yeast Direct injection Micropillar array chromatography Vanquish neo Hela Orbitrap exploris 480 Trap-and-elute 
ProteomicsBenchmarking CHIMERYS using Wide Window Acquisition and Classical Narrow Isolation Window Data Dependent Acquisition
A comprehensive proteome map is essential to elucidate molecular pathways and protein functions. Although great improvements in sample preparation, instrumentation and data analysis already yield-ed impressive results, current studies suffer from a limited proteomic depth and dynamic range there-for...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) Escherichia coli Saccharomyces cerevisiae (Baker's yeast) 
2024-02-13 | PXD045500 | Pride
E. coli Wide window acquisition Yeast Direct injection Micropillar array chromatography Vanquish neo Hela Orbitrap exploris 480 Single cells Trap-and-elute 
ProteomicsATP13A3 is a major component of the enigmatic mammalian polyamine transport system
Polyamines, including putrescine (PUT), spermidine (SPD) and spermine (SPM), are abundant polycations supporting various cellular functions. Their cellular content is tightly controlled by biosynthesis, degradation and uptake or export via the polyamine transport system (PTS). However, the mammalian...
ORGANISM(S): Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 
2020-12-09 | PXD020559 | Pride
Polyamines Putrescine Q exactive hf Atp13a3 P5b-atpase Cho cells Polyamine transport system 
ProteomicsWide Window Acquisition and AI-based data analysis to reach deep proteome coverage for a wide sample range, including single cell proteomic inputs – Co-immunoprecipitation samples
A comprehensive proteome map is essential to elucidate molecular pathways and protein functions. Although great improvements in sample preparation, instrumentation and data analysis already yielded impressive results, current studies suffer from a limited proteomic depth and dynamic range therefore ...
ORGANISM(S): Mus musculus (Mouse) 
2024-02-13 | PXD037985 | Pride
Mus musculus Co-immunoprecipitation Micropillar array chromatography Smarca5 Orbitrap exploris 480 Ultimate3000 rslcnano Protein-protein interactions Trap-and-elute 
ProteomicsImmunopeptidomics-based design of highly effective mRNA vaccine formulations against Listeria monocytogenes
Listeria monocytogenes is a foodborne intracellular bacterial pathogen leading to human listeriosis. Despite a high mortality rate and increasing antibiotic resistance no clinically approved vaccine against Listeria is available. To identify antigens for this bacterial pathogen that can be encoded i...
ORGANISM(S): Homo sapiens (Human) Listeria monocytogenes EGD 
2022-09-26 | PXD031451 | Pride
Tmt Fusion lumos Listeria monocytogenes Hela Immunopeptidomics Epitope discovery Bacterial infection Label-free Q exactive hf Hct-116 Antigen discovery Vaccine development 
ProteomicsSingle-cell transcriptional profiling identifies a spectrum of unconventional intraepithelial T lineage cells in human cord blood
Conventional CD4 and CD8 single positive T cell lineages constitute the main differentiation pathway in the thymus. In human thymus, a minor TCRαβ differentiation pathway diverges from the early double positive stage, consisting of CD10+ PD-1+ cells. These cells are phenotypically and functionally s...
ORGANISM(S): Homo sapiens (Human) 
2023-02-10 | PXD033392 | Pride
Agonist-selection T cell lineages Shotgun proteomics Q exactive hf Human Intraepithelial t cells Cord blood Label-free Thymus 
ProteomicsHDAC6 inhibition restores TDP-43 pathology and axonal transport defects in human motor neurons with TARDBP mutations
TDP-43 is the major component of pathological inclusions in most ALS patients and in up to 50% of patients with frontotemporal dementia (FTD). Heterozygous missense mutations in TARDBP, the gene encoding TDP-43, are one of the common causes of familial ALS. In this study, we investigate TDP-43 prote...
ORGANISM(S): Homo sapiens (Human) 
2021-03-15 | PXD023852 | Pride
Induced pluripotent stem cells Axonal transport Tdp-43 Als Tardpb mutation Hdac6 Interactome 
ProteomicsEicosadomics, proteomics and metabolomics of inflammatory stimulated human fibroblasts reveals specific functions related to chronic inflammation - secreted proteins of inflammatory stimulated cells
Fibroblasts have only recently been identified as important effector cells in inflammation. In this study, human dermal fibroblasts were inflammatory stimulated with interleukin-1beta and comprehensively analysed with respect to proteins, eicosanoids and metabolites. For eicosadomics, we have establ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-02 | MSV000080879 | MassIVE
ProteomicsEicosadomics, proteomics and metabolomics of inflammatory stimulated human fibroblasts reveals specific functions related to chronic inflammation - cytoplasmic proteins of dexamethasone-treated inflammatory stimulated cells
Fibroblasts have only recently been identified as important effector cells in inflammation. In this study, human dermal fibroblasts were inflammatory stimulated with interleukin-1beta and comprehensively analysed with respect to proteins, eicosanoids and metabolites. For eicosadomics, we have establ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-16 | MSV000080644 | MassIVE
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