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ProteomicsElevated Levels of Arsenic Trioxide Promote Divergent SUMOylation
ATO is a therapeutic agents used to treat APL, a disease caused by a chromosomal translocation of the RARα gene that can occur reciprocally with the PML gene. The mechanisms through which ATO function and how increased levels of ATO adversely affect the cell are not fully characterized though they i...
ORGANISM(S): Homo sapiens (Human) 
2020-04-06 | PXD016166 | Pride
Phosphoproteomics. Parp1 Sumoylation Lc-ms Arsenic trioxide Post-translational modifications Caspase 
ProteomicsAccurate quantitative proteomic analyses using metabolic labeling and High Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS)
Stable isotope labeling by amino acids in cell culture (SILAC) is routinely used to profile changes in protein and peptide abundance across different experimental paradigms. As with other quantitative proteomic approaches, the detection of peptide isotopomers can be limited by the presence of interf...
ORGANISM(S): Homo sapiens (Human) 
2019-05-28 | PXD012924 | Pride
Phosphorylation High field asymmetric waveform ion mobility spectrometry (faims) Stable isotope labeling by amino acids in culture (silac) Quantitative proteomics 
ProteomicsSequential Peptide Immunopurification Methodology to Monitor the Crosstalk between SUMOylation and Ubiquitylation
We describe a method that permits the identification of proteins that are modified by both SUMOylation and ubiquitylation to better understand the role of this crosstalk. The procedure requires 3 days when starting from cell pellets and can yield more than 8000 SUMO sites and 3500 ubiquitin sites fr...
ORGANISM(S): Homo sapiens (Human) 
2018-03-27 | PXD006545 | Pride
Sumo Ubiquitin Shotgun proteomics 
ProteomicsQuantitative proteomics identifies novel PIAS1 protein substrates involved in cell migration and motility
The Protein Inhibitor of Activated STAT 1 (PIAS1) is an E3 SUMO ligase that plays important roles in various cellular pathways, including STAT signaling, p53 pathway, and the steroid hormone signaling pathway. PIAS1 can SUMOylate PML (at Lys-65 and Lys-160) and PML-RARα promoting their ubiquitin-med...
ORGANISM(S): Homo sapiens (Human) 
2020-02-06 | PXD011932 | Pride
Pias1 Vimentin Cell invasion Sumoylation Quantitative proteomics 
Proteomicsinterferon-induced global cellular SUMOylation Changes
This proteomics dataset was generated to study the changes in SUMO site abundances between control cells and Interferon-alpha treated cells using SILAC. Cells were first fractionated into the cytoplasmic and nuclear fractions. SUMOylated proteins were then purified from these extracts by Ni-NTA via ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000081525 | MassIVE
ProteomicsA novel differential ion mobility interface expands the depth of proteome coverage and the sensitivity of multiplex proteomic measurements
We present a new high field asymmetric waveform ion mobility spectrometry (FAIMS) interface that can be coupled to the Orbitrap Tribrid mass spectrometers. The interface provides several advantages over previous generations of FAIMS devices including ease of operation, robustness, and high ion trans...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-04-19 | MSV000082293 | MassIVE
UnknownImpact of Complete Revascularization in the ISCHEMIA Trial.
Not available
S-EPMC10529674 | biostudies-literature
UnknownDeath following pulmonary complications of surgery before and during the SARS-CoV-2 pandemic.
Not available
S-EPMC10364875 | biostudies-literature
UnknownInitial Invasive or Conservative Strategy for Stable Coronary Disease.
Not available
S-EPMC7263833 | biostudies-literature
UnknownFactors Associated With Coronary Angiography Performed Within 6 Months of Randomization to the Conservative Strategy in the ISCHEMIA Trial.
Not available
S-EPMC11187765 | biostudies-literature
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