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ProteomicsChemical proteomics identifies a novel off-target protein of small molecule NLRP3 inflammasome inhibitor MCC950
Inhibition of inflammasome and pyroptotic pathways are promising strategies for clinical treatment of autoimmune and inflammatory disorders. MCC950, a potent inhibitor of the NLR-family inflammasome pyrin domain-containing 3 (NLRP3) protein, has shown encouraging results in animal models for a range...
ORGANISM(S): Homo sapiens (Human) 
2021-05-17 | PXD024915 | Pride
Human Mcc950 Thp1 Lc-ms/ms 
ProteomicsChemical proteomics identifies a novel off-target protein of small molecule NLRP3 inflammasome inhibitor MCC950
Inhibition of inflammasome and pyroptotic pathways are promising strategies for clinical treatment of autoimmune and inflammatory disorders. MCC950, a potent inhibitor of the NLR-family inflammasome pyrin domain-containing 3 (NLRP3) protein, has shown encouraging results in animal models for a range...
ORGANISM(S): Homo sapiens (Human) 
2021-05-17 | PXD024913 | Pride
Human Mcc950 Thp1 Lc-ms/ms 
ProteomicsNLRP3 inflammasome modulates methamphetamine-induced hippocampal neurotoxicity and aberrant neurogenesis
Methamphetamine (METH) is known to induce the loss of dopaminergic terminals and impairment of cognitive, emotional, and motor functions. Even though METH is a proinflammatory agent, the role of inflammasomes in its neurotoxic effects is not fully understood. In the present study, we assessed the im...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-14 | PXD066569 | Pride
Neuroinflammation Hippocampus Cognition Mcc950 Nlrp3 inflammasome Methamphetamine Behavior 
UnknownMCC950 closes the active conformation of NLRP3 to an inactive state.
Not available
S-EPMC7116292 | biostudies-literature
UnknownProtection of Mcc950 against high-glucose-induced human retinal endothelial cell dysfunction.
Not available
S-EPMC5550855 | biostudies-literature
UnknownMCC950 targets the ROS-NEK7-NLRP3 axis to improve type 2 diabetic retinopathy.
Not available
S-EPMC12457656 | biostudies-literature
UnknownMCC950, the NLRP3 Inhibitor, Protects against Cartilage Degradation in a Mouse Model of Osteoarthritis.
Not available
S-EPMC8580635 | biostudies-literature
UnknownThe selective NLRP3 inhibitor MCC950 hinders atherosclerosis development by attenuating inflammation and pyroptosis in macrophages.
Not available
S-EPMC8481539 | biostudies-literature
UnknownSelective NLRP3 Inflammasome Inhibitor MCC950 Suppresses Inflammation and Facilitates Healing in Vascular Materials.
Not available
S-EPMC10369291 | biostudies-literature
TranscriptomicsRNA-seq of mouse sciatic peripheral nerve of injured mouse with implant: control (untreated) vs local delivery of MCC950 (NLRP3inh) vs standard FBR treatment dexamethasone (Dex). .
RNA-seq comparing expression profile of peripheral nerve damage and microchannel device implantation repair model: control vs local delivery of MCC950 (NLRP3inh) vs standard FBR treatment dexamethasone (Dex).
ORGANISM(S): Mus musculus 
2022-04-30 | E-MTAB-10293 | biostudies-arrayexpress
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