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ProteomicsPhosphoproteomic Analysis of Mec1/ATR Signaling in Response to Different Manners of Kinase Activation
The Mec1/ATR kinase coordinates multiple cellular responses to replication stress. In addition to its canonical role in activating the checkpoint kinase Rad53, Mec1 also plays checkpoint-independent roles in genome maintenance that are not well understood. Here we employed a combined genetic-phospho...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-01-14 | PXD009734 | Pride
Atr Phosphoproteomics Mec1 Dna2 Dpb11 Ddc1 
TranscriptomicsDNA damage responses and Mec1p
Eukaryotic cells respond to DNA damage by arresting the cell cycle and modulating gene expression to ensure efficient DNA repair. The human ATR kinase and its homolog in yeast, MEC1, play central roles in transducing the damage signal. To characterize the role of the Mec1 pathway in modulating the c...
ORGANISM(S): Saccharomyces cerevisiae 
2005-09-24 | E-GEOD-3358 | biostudies-arrayexpress
TranscriptomicsRNA processing proteins regulate Mec1/ATR activation by promoting generation of RPA-coated ssDNA.
Eukaryotic cells respond to DNA double-strand breaks (DSBs) by activating a checkpoint that depends on the protein kinases Tel1/ATM and Mec1/ATR. Mec1/ATR is activated by RPA-coated single-stranded DNA (ssDNA), which arises upon nucleolytic degradation (resection) of the DSB. Emerging evidences indi...
ORGANISM(S): Saccharomyces cerevisiae 
2014-11-20 | E-GEOD-63444 | biostudies-arrayexpress
ProteomicsPhosphoproteomic Datasets for Mec1/ATR Signaling Upon Hyper-Resection
The Mec1/ATR kinase is crucial for genome maintenance, although the mechanisms by which it controls DNA repair pathways remain elusive. Here we uncovered a role for Mec1/ATR in controlling homologous recombination (HR) factors in response to hyper-resection of DNA ends. Cells lacking RAD9, a checkpo...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-03-10 | PXD017286 | Pride
Atr Mec1 Dna repair Dna damage Yeast Sgs1 Resection 
ProteomicsPhosphoproteomic Datasets for Mec1/ATR signaling in Checkpoint-deficient (rad53Δ) cells
The Mec1/ATR kinase is crucial for genome stability, yet the mechanism by which it prevents gross chromosomal rearrangements (GCRs) remains unknown. Here we find that in cells with deficient Mec1 signaling, GCRs accumulate due to the deregulation of multiple steps in homologous recombination (HR). M...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-06-05 | PXD051892 | Pride
Mec1/atr Saccharomyces cerevisiae (baker's yeast) Dna damage checkpoint 
TranscriptomicsRNA processing proteins regulate Mec1/ATR activation by promoting generation of RPA-coated ssDNA.
Eukaryotic cells respond to DNA double-strand breaks (DSBs) by activating a checkpoint that depends on the protein kinases Tel1/ATM and Mec1/ATR. Mec1/ATR is activated by RPA-coated single-stranded DNA (ssDNA), which arises upon nucleolytic degradation (resection) of the DSB. Emerging evidences indi...
ORGANISM(S): Saccharomyces cerevisiae 
2014-11-20 | GSE63444 | GEO
UnknownPhosphoproteomics reveals distinct modes of Mec1/ATR signaling during DNA replication.
Not available
S-EPMC4369404 | biostudies-literature
ProteomicsPhosphoproteomic Datasets for Mec1/ATR Signaling Upon Hyper-Resection (TMT Supplement)
The Mec1/ATR kinase is crucial for genome maintenance, although the mechanisms by which it controls DNA repair pathways remain elusive. Here we uncovered a role for Mec1/ATR in controlling homologous recombination (HR) factors in response to hyper-resection of DNA ends. Cells lacking RAD9, a checkpo...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-03-10 | PXD023438 | Pride
Mec1 Sgs1 Silac Phosphoproteomics Resection 
UnknownPhosphoproteomics reveals a distinctive Mec1/ATR signaling response upon DNA end hyper-resection.
Not available
S-EPMC8126923 | biostudies-literature
UnknownRNA-processing proteins regulate Mec1/ATR activation by promoting generation of RPA-coated ssDNA.
Not available
S-EPMC4328749 | biostudies-literature
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