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TranscriptomicsDNA copy number profiles of premalignant endobronchial lesions: a validated predictor for endobronchial cancer
Individuals who present with premalignant endobronchial lesions are considered at high risk of lung cancer. Nonetheless, premalignant lesions behave erratically and only a minority progresses towards lung cancer. Therefore, biomarkers need to be discovered that can aid in assessing an individual’s r...
ORGANISM(S): Homo sapiens 
2013-12-03 | E-GEOD-45287 | biostudies-arrayexpress
TranscriptomicsRunx1 is a tumor suppressor gene in the mouse gastrointestinal tract
The Runx1 transcription factor plays an important role in tissue homeostasis through its effects on stem/progenitor cell populations and differentiation. The effect of Runx1 on epithelial differentiation of the secretory cell lineage of the colon was recently demonstrated. This study aimed to examin...
ORGANISM(S): Mus musculus 
2012-09-13 | E-GEOD-34292 | biostudies-arrayexpress
GenomicsNKI-AvL TGO DAC
Data Access Committee EGAC00001001051
EGAC00001001051 | EGA
TranscriptomicsAltered microRNA expression associated with chromosomal and epigenetic changes contributes to cervical carcinogenesis
Little is known about the alterations in microRNA (miRNA) expression patterns during the consecutive stages of cervical cancer development and their association with chromosomal instability and epigenetic changes. We integrated miRNA expression profiles in normal cervical squamous epithelium, high-g...
ORGANISM(S): Homo sapiens 
2012-06-27 | E-GEOD-30656 | biostudies-arrayexpress
TranscriptomicsCopy Number Alterations in HNSCC with or without Oncogene Expressing Human Papillomavirus
Oncogene expressing human papillomavirus type 16 (HPV16) is found in a subset of head and neck squamous cell carcinomas (HNSCC). HPV16 drives carcinogenesis by inactivating p53 and pRb with the viral oncoproteins E6 and E7, reflected by a low level of mutations in TP53 and allelic loss at 3p, 9p and...
ORGANISM(S): Homo sapiens 
2009-05-26 | E-GEOD-11931 | biostudies-arrayexpress
TranscriptomicsHead and neck squamous cell carcinomas
This SuperSeries is composed of the following subset Series: GSE11929: Identification of a subgroup of head and neck cancers lacking numerical chromosomal aberrations GSE11931: Copy Number Alterations in HNSCC with or without Oncogene Expressing Human Papillomavirus Refer to individual Series
ORGANISM(S): Homo sapiens 
2009-03-11 | E-GEOD-12020 | biostudies-arrayexpress
TranscriptomicsArray CGH on gemcitabine resistant tumor
Biological material: One solid mouse tumor "Colon 26A" was routinely maintained by successive transplantation. A subset of mice with this tumor was treated at the maximum tolerable dosage of Gemcitabine and successively transplanted 5 times and similarly treated. The last passage was completly resis...
ORGANISM(S): Mus musculus 
2010-06-05 | E-GEOD-2373 | biostudies-arrayexpress
TranscriptomicsExpression microarray analysis of acquired gemcitabine resistance
This series repressents the data set from the paper "Expression microarray analysis and oligo array CGH of aquired gemcitabine resistance in mouse colon reveals selection for chromosomal aberrations". Biological material: One solid mouse tumor "Colon 26A" was routinely maintained by successive tran...
ORGANISM(S): Mus musculus 
2010-06-05 | E-GEOD-2352 | biostudies-arrayexpress
TranscriptomicsLosses of chromosome 5q and 14q mark a subset of gastric cancers with good clinical outcome
Purpose: To improve clinical outcome of gastric cancer patients, most emphasis is on improving therapeutic regimens, including more extensive surgery as well as (neo)adjuvant chemotherapy. The present study set out to identify, based on DNA copy number profiling, subgroups of patients with different...
ORGANISM(S): Homo sapiens 
2012-05-09 | E-GEOD-26389 | biostudies-arrayexpress
TranscriptomicsCandidate driver genes in focal chromosomal aberrations of stage II colon cancer
Chromosomal instable colorectal cancer is marked by specific large chromosomal copy number aberrations. Recently, focal aberrations of 3Mb or smaller have been identified as a common phenomenon in cancer. Inherent to their limited size, these aberrations harbour one or few genes. The aim of this stu...
ORGANISM(S): Homo sapiens 
2010-04-19 | E-GEOD-17047 | biostudies-arrayexpress
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