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TranscriptomicsOrientation-Specific Joining of AID-initiated DNA Breaks Promotes Antibody Class Switching
During B cell development, RAG endonuclease cleaves immunoglobulin heavy chain (IgH) V, D, and J gene segments and orchestrates their fusion as deletional events that assemble a V(D)J exon in the same transcriptional orientation as adjacent Cμ constant region exons. In mice, six additional sets of c...
ORGANISM(S): Mus musculus 
2015-08-26 | E-GEOD-71005 | biostudies-arrayexpress
UnknownOrganophotocatalytic Selective Deuteration of Metabolically Labile Heteroatom Adjacent C-H Bonds via H/D Exchange with D<sub>2</sub>O.
Not available
S-EPMC11527481 | biostudies-literature
UnknownOrganophotocatalytic α-deuteration of unprotected primary amines <i>via</i> H/D exchange with D<sub>2</sub>O.
Not available
S-EPMC10872390 | biostudies-literature
UnknownAssociation between variants in vitamin D-binding protein gene and vitamin D deficiency among pregnant women in china.
Not available
S-EPMC7521226 | biostudies-literature
ProteomicsGlobal Phosphoproteomics Reveals Molecular Networks in Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is a systemic and heterogeneous autoimmune disease for which its treatment and phosphorylation-dependent regulatory mechanism remain elusive. Here, we aim to explore the molecular mechanism of phosphorylation regulation for SLE. We employed high-throughput Phosphop...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD025076 | Pride
Phosproteomics  sle remission stage  sle active stage  kinases  parallel reaction monitoring 
UnknownProtein tyrosine phosphatase receptor type D (PTPRD)-mediated signaling pathways for the potential treatment of hepatocellular carcinoma: a narrative review.
Not available
S-EPMC7576031 | biostudies-literature
UnknownCronobacter spp. in Commercial Powdered Infant Formula Collected From Nine Provinces in China: Prevalence, Genotype, Biofilm Formation, and Antibiotic Susceptibility.
Not available
S-EPMC9197194 | biostudies-literature
TranscriptomicsPathways leading to phosphorylation of p450c17 and to the post-translational regulation of androgen biosynthesis
Cytochrome P450c17 (P450c17) is the single enzyme that catalyzes steroid 17alpha-hydroxylase and 17,20 lyase activities and hence is the crucial decision-making step that determines the class of steroid made in a steroidogenic cell. Although both activities are catalyzed on a single active site, the...
ORGANISM(S): Homo sapiens 
2013-02-15 | E-GEOD-44311 | biostudies-arrayexpress
ProteomicsPodophyllum Hexandrum Royle MALDI-TOF-MS/MS
With the aim of reveal the mechanism of Podophyllum Hexandrum Royle adaption to high altitude, MALDI-TOF-MS/MS in combination with 2-DE was used to identify the differentially expressed proteins in leaves of Podophyllum Hexandrum Royle between low altitude (2200m) and high altitude (3100m), 65 diffe...
ORGANISM(S): Sinopodophyllum hexandrum 
2023-03-10 | PXD005640 | Pride
Podophyllum hexandrum royle Altitude Maldi-tof-ms/ms 
ProteomicsThe ubiquitin E3 ligase APC/CCdc20 mediates mitotic degradation of OGT
O-linked β-N-acetylglucosamine (O-GlcNAc) transferase (OGT) is the sole enzyme that catalyzes all O-GlcNAcylation reactions intracellularly. Previous investigations have found that OGT levels oscillate during the cell division process. Specifically, OGT abundance is downregulated during mitosis, but...
ORGANISM(S): Homo sapiens (Human) 
2024-08-10 | PXD050552 | Pride
Uterine carcinoma Ubiquitination Cell cycle Ogt Apc/ccdc20 
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