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MetabolomicsComparative metabolomics analysis reveals high-altitude adaptations in a toad-headed viviparous lizard, Phrynocephalus vlangalii
Extreme environmental conditions at high altitude, such as hypobaric hypoxia, low temperature, and strong UV radiation, pose a great challenge to the survival of animals. Although the mechanisms of adaptation to high-altitude environments have attracted much attention for native plateau species, the...
2024-01-16 | MTBLS6900 | MetaboLights
MetabolomicsIsoquercitrin alleviates subchronic high-altitude hypoxia-induced myocardial injury by regulating mitochondrial energy metabolism and maintaining immune–inflammatory homeostasis
High-altitude hypoxia induces myocardial metabolic disorders, structural remodeling, and functional impairment, which threaten the health of highland populations. The interventional effects and molecular mechanisms of isoquercitrin (IQ), a natural flavonoid with cardiovascular protective activity, a...
2026-07-29 | MTBLS15192 | MetaboLights
MetabolomicsMulti-omics Analysis Reveals New Insights into Yak Lung Fibrosis Mechanisms Under High-Altitude Adaptation

The lung of yak is an important adaptive organ in the cold and low oxygen environment. Hypoxia can induce the pathological manifestations of pulmonary fibrosis in yak, but there was no study on hypoxia induced pulmonary fibrosis in yak. In this study full target metabolomics were used to conduct ...

2025-07-07 | MTBLS11648 | MetaboLights
ProteomicsDeep crotonylproteomics analysis of high-altitude exposure hearts in mice
Background: The potential molecular mechanisms underlying acute adaptation and chronic remodeling of cardiac structure and function in response to high altitude are not yet fully understood. This study aims to investigate changes in the crotonylproteome in the hearts of mice exposed to high altitude...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD044178 | Pride
Crotonylation  heart  high altitude  metabolism  muscle 
ProteomicsAlterations of human plasma proteome profile on adaptation to high-altitude hypobaric hypoxia
For individuals migrating to or residing permanently at high-altitude regions, environmental hypobaric hypoxia is a primary challenge which induces several physiological or pathological responses. It is well documented that human beings adapt to hypobaric hypoxia via some protective mechanisms, such...
ORGANISM(S): Homo sapiens (Human) 
2019-03-27 | PXD012221 | Pride
Proteomics  high altitude  hypobaric hypoxia  complement and coagulation cascades  antioxidant  glycolysis. 
ProteomicsDecoding altitude – activated regulatory mechanisms underlining apple peel coloration and ripening
Apple (Malus domestica Borkh) is an important fruit crop cultivated in a broad range of environmental conditions. Apple fruit, and specifically peel tissue, ripening is a physiological process whose molecular regulatory networks response to different environments are still not sufficiently investiga...
ORGANISM(S): Malus domestica 
2021-09-08 | PXD017037 | Pride
Proteomics Ripening Metabolomics Anthocyanin Peel tissue Apple fruit Altitude 
ProteomicsDecoding altitude ��� activated regulatory mechanisms underlining apple peel coloration and ripening
Apple (Malus domestica Borkh) is an important fruit crop cultivated in a broad range of environmental conditions. Apple fruit, and specifically peel tissue, ripening is a physiological process whose molecular regulatory networks response to different environments are still not sufficiently investiga...
ORGANISM(S): Malus domestica 
2021-11-25 | PXD017057 | Pride
Proteomics Ripening Metabolomics Anthocyanin Peel tissue Apple fruit Altitude 
TranscriptomicsGene expression profiling under exposure to high altitude hypoxic environment
Understanding molecular mechanism associated with high altitude exposure during acclimatization/adaptation/maladaptation. Data reveals specific components of the complex molecular circuitry underlying high altitude pulmonary edema. Individualized outcome prediction were constructed through expressio...
ORGANISM(S): Homo sapiens 
2013-12-18 | E-GEOD-52209 | biostudies-arrayexpress
TranscriptomicsEffects of chronic hypoxia on Duchenne Muscular Dystrophy Drosophila melanogaster model
In order to understand the chronic hypoxia (CH) effect upon the absence of dystrophin, Drosophila melanogaster wild type and the model for DMD (dmDys), in which all dystrophins expression was knocked out by iRNA, were exposed to high altitude hypoxia (hypobaric hypoxia) during a 16-day climbing per...
ORGANISM(S): Drosophila melanogaster 
2010-07-31 | E-GEOD-15879 | biostudies-arrayexpress
ProteomicsComparative proteomics analysis reveals the adaptation strategies of the alpine plant Potentilla saundersiana along the altitude gradient of the Northwestern Tibetan Plateau
The altitude gradient limits the growth and distribution of alpine plants.Alpine plants have developed strategies to survive the extremely cold conditions prevailing at high altitudes; however, the mechanism underlying the evolution of these strategies remains unknown. The alpine plant Potentilla sa...
ORGANISM(S): Potentilla saundersiana 
2022-02-22 | PXD001112 | Pride
Comparative proteomics  potentilla saundersiana  adaptation 
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