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TranscriptomicsTranscription profiling by array of rat cerebral cortex and hippocampus from animals with pneumococcal meningitis treated with dexamethasone
Effect of adjuvant dexamethasone treatment on gene expression in the hippocampus and cortex of control rats or rats suffering from pneumococcal meningitis which were sacrificed 72 h after infection.
ORGANISM(S): Rattus norvegicus 
2011-02-28 | E-MEXP-2953 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat hippocampus and cortex in the time series of Pneumococcal Meningitis infection
The aim of this work is to describe the transcriptomic changes underlying the complex mechanisms of the host response to pneumococcal meningitis in a temporal and spatial context. For this purpose we evaluated the gene expression profile of the two brain structures predominantly affected by brain da...
ORGANISM(S): Rattus norvegicus 
2010-02-24 | E-MEXP-1656 | biostudies-arrayexpress
TranscriptomicsVitamin B6 reduces hippocampal apoptosis in experimental pneumococcal meningitis
Hippocampal apoptosis is a characteristic feature of penumococcal meningitis associated with learning and memory deficitis as a sequel of the disease. We investigated the effect of vitamin B6 using an established infant rat model of experimental pneumococcal meningitis by histomorphology, transcript...
ORGANISM(S): Rattus norvegicus 
2012-02-20 | E-MEXP-3555 | biostudies-arrayexpress
TranscriptomicsInflammasome-dependent Interferon-gamma drives pathogenesis in Streptococcus pneumoniae meningitis.
A comparison of brain gene expression profiles in wildtype mice and interferon gamma -/- mice during bacterial meningitis.
ORGANISM(S): Mus musculus 
2012-09-01 | E-MEXP-3697 | biostudies-arrayexpress
ProteomicsCerebrospinal fluid markers to distinguish bacterial meningitis from cerebral malaria in children
Clinically distinguishing acute bacterial meningitis from cerebral malaria, both of which are important causes of acute non-traumatic coma associated with morbidity and mortality among paediatric hospital admissions in malaria endemic areas of Africa, is challenging. Few hospitals have diagnostic ca...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-24 | MSV000080979 | MassIVE
ProteomicsCerebrospinal fluid proteome maps detect pathogen-specific host response patterns in meningitis
Meningitis is a life-threatening condition characterized by the inflammation of the leptomeningeal membranes surrounding the brain and spinal cord. The term meningitis is an umbrella term and includes several different etiologies. The majorities of meningitis cases are caused by viruses (viral menin...
ORGANISM(S): Homo sapiens (Human) 
2021-04-12 | PXD023174 | Pride
Human Cerebrospinal fluid Meningitis 
TranscriptomicsPeripheral blood RNA gene expression profiling in patients with bacterial meningitis
The aim of present study was to describe the genetic pathways activated during the community acquired bacterial meningitis (BM) by using genome-wide RNA expression profiling combined with functional annotation of transcriptional changes. We included 21 patients with BM hospitalized in 2008. The cont...
ORGANISM(S): Homo sapiens 
2012-09-05 | E-GEOD-40586 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of pneumococcal virulence factors expressed during meningitis in mice
Streptococcus pneumoniae is the most common cause of severe bacterial meningitis in children, the elderly, and immunocompromised individuals. To identify virulence factors preferentially expressed during meningitis, we conducted niche-specific genome-wide in vivo transcriptomic analysis after intran...
ORGANISM(S): Streptococcus pneumoniae 
2012-04-10 | E-BUGS-130 | biostudies-arrayexpress
TranscriptomicsGenome-wide identification of Streptococcus pneumoniae genes essential for the development of experimental meningitis
We applied genomic array footprinting (GAF) in the search for genes of S. pneumoniae essential during the establishment and progression of experimental meningitis. Four libraries with a total of 6,000 independent TIGR4 marinerT7 transposon mutants were injected intra-cisternally in rabbits, and cere...
ORGANISM(S): Streptococcus pneumoniae 
2010-11-16 | E-GEOD-21729 | biostudies-arrayexpress
ProteomicsNeutrophil extracellular traps in the central nervous system: a novel therapeutic target in pneumococcal meningitis.
Neutrophils are crucial mediators of host defense and are recruited to the central nervous system in large numbers during acute bacterial meningitis caused by S. pneumoniae. Neutrophils can release neutrophil extracellular traps (NETs) during infections to trap and kill bacteria. Intact NETs are fib...
ORGANISM(S): Homo sapiens (Human) Streptococcus pneumoniae TIGR4 
2019-11-12 | PXD011546 | Pride
Nets neutrophil pneumococci meningitis dda swath 
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