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ProteomicsCOLLAGEN POST-TRANSLATIONAL MODIFICATIONS ARE ALTERED IN IPF INCLUDING WITHIN ECM RECEPTOR BINDING MOTIFS
Idiopathic pulmonary fibrosis (IPF) is a fatal chronic lung disease with a median survival of 3.8 years, a prevalence of 10 to 60 cases per 100,000 in the United States, and rising incidence and mortality rates. Currently approved antifibrotic agents can slow disease progression but are insufficient...
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD066357 | Pride
Lc-msms Collagen Ipf 
ProteomicsCholesterol Regulates Airway Epithelial Cell Differentiation by Inhibiting p53 Nuclear Translocation
Cholesterol is an essential plasma membrane component, and altered cholesterol metabolism has been linked to cholesterol accumulation in the airways of COPD and cystic fibrosis patients. However, its role in airway epithelial differentiation is not well understood. Tandem mass spectrometry-based pro...
ORGANISM(S): Homo sapiens (Human) 
2025-09-22 | PXD063763 | Pride
Ingenuity pathway analysis Primary human bronchial epithelial cells Cholesterol P53 
ProteomicsCigarette smoke alters the secretome of lung epithelial cells
Cigarette smoke is the most relevant risk factor for the development of lung cancer and chronic obstructive pulmonary disease. Many of its more than 4500 chemicals are highly reactive, thereby altering protein structure and function. Here, we used subcellular fractionation coupled to label-free quan...
ORGANISM(S): Homo sapiens (Human) 
2019-01-08 | PXD007180 | Pride
Lung Proteomic profiling Cigarette smoke Secretome 
ProteomicsProteomic profiling reveals central role of STAT signaling during retinal degeneration in the rd10 mouse model
The rd10 mouse is a model of retinitis pigmentosa characterized by the dysfunction of a rod-photoreceptor-specific phosphodiesterase. Compared to the rd1 mouse, retinal degeneration in the rd10 mouse begins later in age with a milder phenotype, making it ideal for investigating cell death and neurop...
ORGANISM(S): Mus musculus (Mouse) 
2016-03-21 | PXD002584 | Pride
Label-free mass spectrometry  phospho-stat  retinal müller glial cells 
ProteomicsCross-talk between monocyte invasion and astrocyte proliferation regulates scarring in brain injury
Scar formation after brain injury is still ill understood. Here we examined the interplay between astrocyte proliferation and monocyte invasion. Using genetic mouse models to decrease or increase reactive astrocyte proliferation, we demonstrate inverse effects on monocyte numbers in the injury site,...
ORGANISM(S): Mus musculus (Mouse) 
2018-04-16 | PXD008906 | Pride
Lc-msms Brain 
ProteomicsDissecting the molecular effects of cigarette smoke on proteasome function
Proteasome dysfunction is emerging as a novel pathomechanism for the development of chronic obstructive pulmonary disease (COPD), a major leading cause of death in the world. Cigarette smoke is one of the main risk factors for COPD and has been shown to impair proteasome function in vitro and in viv...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2019-01-08 | PXD007148 | Pride
Cigarette smoke Proteasome 
ProteomicsProtein expression plasticity contributes to heat and drought tolerance of date palm
Climate change is increasing the frequency and intensity of warming and drought periods around the globe, currently representing a threat to many plant species. Understanding the resistance and resilience of plants to climate change is, therefore, urgently needed. As date palm (Phoenix dactylifera) ...
ORGANISM(S): Phoenix dactylifera 
2022-02-16 | PXD021666 | Pride
Abiotic stress  heat and drought  isoprene  voc emissions  proteomics  photosynthesis  phoenix dactylifera 
ProteomicsA comprehensive view on r- protein binding and rRNA domain structuring during early ribosome formation
Formation of the eukaryotic ribosomal subunits follows a strict regime to assemble ribosomal proteins (r-protein) with ribosomal RNAs (rRNA) while removing internal (ITS) and external (ETS) transcribed rRNA spacers. During early stages of large subunit (LSU) formation, ITS2 together with six assembl...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-02-02 | PXD058994 | Pride
Ribosome biogenesis Single particle cryo-em Lsu assembly Ssu processome Rrna domain folding Ribosomal protein assembly 
ProteomicsThe novel ribosome biogenesis inhibitor usnic acid blocks nucleolar pre-60S maturation
The formation of new ribosomes is tightly coordinated with cell growth and proliferation. In eukaryotes, the correct assembly of all ribosomal proteins and RNAs involves an intricate cascade of maturation and rearrangement steps across three cellular compartments: the nucleolus, nucleoplasm, and cyt...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-10-17 | PXD046691 | Pride
Yeast 60s Ribosome biogenesis Lc-msms 
ProteomicsRNAi-mediated downregulation of poplar plasma membrane intrinsic proteins (PIPs) changes plasma membrane proteome composition and affects leaf physiology
Plasma membrane intrinsic proteins (PIPs) are one subfamily of aquaporins that mediate the transmembrane transport of water. To reveal their function in poplar, we generated transgenic poplar plants in which the translation of PIP genes was downregulated by RNA interference investigated these plants...
ORGANISM(S): Populus canescens (Grey poplar) (Populus tremula x Populus alba) 
2015-08-10 | PXD002544 | Pride
Plasma membrane intrinsic protein  populus × canescens  plasma membrane proteomics  photosynthesis  stomatal movement Aquaporin  pip 
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