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ProteomicsAn OMICS perspective on N-terminal Methionine Excision
Excision of the N-terminal initiator methionine (iMet) from nascent peptide chains is an essential and omnipresent protein modification carried out by Methionine aminopetidases (MetAPs) and accounting for a major source of N-terminal proteoform diversity. While MetAP2 is known to be implicated in pr...
ORGANISM(S): Homo sapiens (Human) 
2018-01-10 | PXD006638 | Pride
Metap Metap1 Shotgun N-terminal proteomics Imet excision 
TranscriptomicsMiR-192 inhibits nucleotide excision repair by targeting ERCC3 and ERCC4 in HepG2.2.15 cells.
Deficient DNA repair capacity is associated with genetic lesions accumulation and susceptibility to carcinogenesis. MicroRNAs (miRNAs) are small non-coding RNAs that regulate various cellular pathways including DNA repair. Here we hypothesized that the existence of HBV products may interfere with ce...
ORGANISM(S): Homo sapiens 
2011-08-02 | E-GEOD-27561 | biostudies-arrayexpress
TranscriptomicsHigh resolution mapping of modified nucleobases in DNA using excision repair enzymes
Data from Excision-seq experiments to map deoxyuridine and pyrimidine dimers in S. cerevisiae and E. coli For uracil mapping in pre-digestion Excision-seq, uracil was excised from genomic DNA from dut ung yeast and bacteria yielding double-stranded DNA fragments. Adapters were ligated to these fragm...
ORGANISM(S): Escherichia coli 
2014-05-15 | E-GEOD-51361 | biostudies-arrayexpress
ProteomicsIdentification of base excision repair protein complexes
We recapitulated two main, cellular base excision repair (BER) complexes (herein termed Complex A, comprised of POLB and XRCC1 and Complex B, XRCC1-devoid complexes) by exploiting a separation-of-function mutant of POLB that does not bind to XRCC1, the V303-loop mutant POLB(TM). Cell lines were deve...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-04-24 | MSV000094615 | MassIVE
UnknownN-terminomics identifies widespread endoproteolysis and novel methionine excision in a genome-reduced bacterial pathogen.
Not available
S-EPMC5593965 | biostudies-literature
ProteomicsFrom incision to excision: active DNA damage eviction by HLTF stimulates repair
Nucleotide excision repair (NER) counteracts the onset of cancer and aging by removing helix-distorting DNA lesions via a ‘cut-and-patch’-type reaction. The regulatory mechanisms that drive NER through its successive damage recognition, verification, incision and gap restoration reaction steps remai...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD031243 | Pride
Uv damage response Hltf Repair synthesis Damage eviction Dna damage Tfiih Genome stability Post-replication repair Nucleotide excision repair 
TranscriptomicsOMICS assisted N-terminal proteoform and protein expression profiling upon methionine aminopeptidase 1 (MetAP1) deletion
Excision of the N-terminal initiator methionine (iMet) residue from nascent peptide chains is an essential and omnipresent protein modification carried out by methionine aminopeptidases (MetAPs) that accounts for a major source of N-terminal proteoform diversity. While MetAP2 is known to be implicat...
ORGANISM(S): Homo sapiens 
2018-01-12 | GSE103405 | GEO
UnknownPyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1.
Not available
S-EPMC3688283 | biostudies-literature
UnknownN-Terminal Modifications of Ubiquitin via Methionine Excision, Deamination, and Arginylation Expand the Ubiquitin Code.
Not available
S-EPMC8926867 | biostudies-literature
UnknownExpression and characterization of Mycobacterium tuberculosis methionine aminopeptidase type 1a.
Not available
S-EPMC2860377 | biostudies-literature
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