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ProteomicsRole for ribosomal quality control in sampling proteins for MHC class I-mediated antigen presentation
Mammalian cells present a fingerprint of their proteome to the adaptive immune system through the display of endogenous peptides on MHC-I complexes. MHC-I peptides originate from protein degradation by the proteasome, suggesting that efficiently-folding, long-lived proteins could evade monitoring. H...
ORGANISM(S): Homo sapiens (Human) 
2020-01-29 | PXD014644 | Pride
Ribosomal quality control Listerin Immunopeptidome Mhc-i 
TranscriptomicsEpigenetic regulations in the IFNM-NM-3 signalling pathway: IFNM-NM-3-mediated MHC class I upregulation on tumour cells is associated with DNA demethylation of antigen-presenting machinery genes [TC1A9_IFN]
Reversible MHC class I deficiency on tumour cells is commonly caused by coordinated silencing of antigen-presenting machinery genes and restorable by IFNM-NM-3. Here we describe association of DNA demethylation of selected antigen-presenting machinery gene regulatory regions located in the MHC geno...
ORGANISM(S): Mus musculus 
2014-12-08 | E-GEOD-53467 | biostudies-arrayexpress
TranscriptomicsEpigenetic regulations in the IFNM-NM-3 signalling pathway: IFNM-NM-3-mediated MHC class I upregulation on tumour cells is associated with DNA demethylation of antigen-presenting machinery genes [TC1A9_DAC]
Reversible MHC class I deficiency on tumour cells is commonly caused by coordinated silencing of antigen-presenting machinery genes and restorable by IFNM-NM-3. Here we describe association of DNA demethylation of selected antigen-presenting machinery gene regulatory regions located in the MHC geno...
ORGANISM(S): Mus musculus 
2014-12-08 | E-GEOD-53466 | biostudies-arrayexpress
TranscriptomicsEpigenetic regulations in the IFNM-NM-3 signalling pathway: IFNM-NM-3-mediated MHC class I upregulation on tumour cells is associated with DNA demethylation of antigen-presenting machinery genes [RVPC3_DAC]
Reversible MHC class I deficiency on tumour cells is commonly caused by coordinated silencing of antigen-presenting machinery genes and restorable by IFNM-NM-3. Here we describe association of DNA demethylation of selected antigen-presenting machinery gene regulatory regions located in the MHC geno...
ORGANISM(S): Mus musculus 
2014-12-08 | E-GEOD-53465 | biostudies-arrayexpress
GenomicsHippo signaling-controlled MHC-I antigen processing and presentation pathway potentiates antitumor immunity
Hippo signaling-controlled MHC-I antigen processing and presentation pathway potentiates antitumor immunity
PRJNA1063716 | ENA
ProteomicsA Systematic Interrogation of MHC Class I Antigen Presentation Identifies Constitutive and Compensatory Protein Degradation Pathways
Peptides presented by MHC Class I were purified from B lymphoblasts or breast cancer cell lines following protein degradation pathway perturbations. Approximately 1E8 total cells were used for each experiment.
ORGANISM(S): Homo sapiens (Human) 
2023-08-03 | PXD032167 | Pride
Autophagy Mhc class i Neddylation Proteasome Ubiquitin Vcp Immunopeptidome P97 
ProteomicsReshaping of the MHC-I ligandome in response to reovirus-based cancer immunotherapy
Oncolytic viruses (OVs), known for their cancer-killing characteristics, overturn tumor-associated defects in antigen presentation through the MHC class I pathway and induce protective neo antitumor CD8 T cell responses. Nonetheless, whether OVs shape the tumor MHC-I ligandome remains unknown. Here,...
ORGANISM(S): Mus musculus (Mouse) 
2019-05-20 | PXD013066 | Pride
Antitumor immunity Reovirus Mhc ligandome Mass spectrometry Cancer immunotherapy Cd8 t cell epitopes Oncolytic virus 
GenomicsAn evolutionarily conserved function of polycomb silences the MHC class I antigen presentation pathway and enables immune evasion in cancer [ChIP-Seq]
An evolutionarily conserved function of polycomb silences the MHC class I antigen presentation pathway and enables immune evasion in cancer [ChIP-Seq]
PRJNA531105 | ENA
GenomicsAn evolutionarily conserved function of polycomb silences the MHC class I antigen presentation pathway and enables immune evasion in cancer [RNA-Seq]
An evolutionarily conserved function of polycomb silences the MHC class I antigen presentation pathway and enables immune evasion in cancer [RNA-Seq]
PRJNA531104 | ENA
ProteomicsHLA-DP(84Gly) constitutively presents endogenous peptides generated by the class I antigen processing pathway
Classical antigen processing/presentation mechanisms lead to the presentation of antigenic peptides derived from endogenous and exogenous sources for MHC class I and class II molecules, respectively. We show here that, unlike other class II, prevalent HLA-DP molecules whose chains encode Gly84 (DP8...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-04 | MSV000080228 | MassIVE
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