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ProteomicsProteomic identification of MHC class I-associated peptidome derived from non-obese diabetic mouse thymus and pancreas
The peptides repertoire presented to CD8+ T cells by major histocompatibility complex (MHC) class I molecules, referred to as the MHC I-associated peptidome (MIP), regulates all critical events that occur during the lifetime of CD8+ T cells. The MIP presented by thymic antigen presenting cells (APCs...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-14 | PXD031966 | Pride
Pancreas Lc-ms/ ms Nod mouse Mhc class i-associated peptidome T1d Cd8+ t-cell. Thymus 
ProteomicsNNAlign_MA; MHC peptidome deconvolution for accurate MHC binding motif characterization and improved T cell epitope predictions
Current mass spectrometry technologies allow for identification of MHC-associated peptide ligands. Studies have proven these data to be a rich source of information for learning the rules of MHC-mediated antigen presentation. Such immunopeptidomes are usually poly-specific, containing multiple seque...
ORGANISM(S): Bos taurus (Bovine) 
2019-10-07 | PXD015240 | Pride
Immunopeptidomics Bola ligandome 
ProteomicsIdentification of a cryptic MHC-E epitope from influenza virus
B6-CIITA-E cell line (C57Bl/6 fibroblasts expressing MHC-II molecules I-Ab and I-Ed) was infected with Influenza A virus (A/Puerto Rico/8/1934, PR8) or left uninfected (control), and the MHC-class II-associated peptidome analysed via immunopeptidomics.
ORGANISM(S): Mus musculus (Mouse) 
2023-10-10 | PXD045025 | Pride
Influenza a virus Viral infection Mhc Immunopeptidomics 
UnknownERAAP Shapes the Peptidome Associated with Classical and Nonclassical MHC Class I Molecules.
Not available
S-EPMC4976029 | biostudies-literature
ProteomicsGlobal proteogenomic analysis of human MHC I peptides derived from noncanonical reading frames
Using highthroughput mass spectrometry, we probed the sixreadingframe translation of human B cells’ transcriptome. We report that about 10% of MHC Iassociated peptides (MAPs) derive from noncanonical reading frames. These socalled cryptic MAPs originate from allegedly non- coding genomic sequences ...
ORGANISM(S): Homo sapiens (Human) 
2016-01-28 | PXD001898 | Pride
Proteogenomic cryptic mhc lc-msms maps 
ProteomicsThe immunopeptidome presents a selected portion of the human genome with distinct features to CD8 T cells
Using proteogenomics, we identified and analyzed 25,172 major histocompatibility complex class I-associated peptides (MAPs) isolated from B lymphocytes of 18 individuals who collectively expressed 27 HLA-A,B allotypes. While 58% of genes were the source of 1-64 MAPs per gene, 42% of genes were not r...
ORGANISM(S): Homo sapiens (Human) 
2016-12-13 | PXD004023 | Pride
Human Lc-msms B lymphoblast Hla-a Hla-b B cell B-lcl Immunopeptidome Mhc class i 
ProteomicsSubstantial Influence of ERAP2 on the HLA-B*40:02 peptidome. Implications for HLA-B*27-negative ankylosing spondylitis.
HLA-B*40:02 is one of a few Major Histocompatibility Complex class I (MHC-I) molecules associated with ankylosing spondylitis (AS) independently of HLA-B*27. The endoplasmic reticulum aminopeptidase 2 (ERAP2), an enzyme that process MHC-I ligands and preferentially trims N-terminal basic residues, i...
ORGANISM(S): Homo sapiens (Human) 
2019-09-25 | PXD014804 | Pride
Hla-b*40:02 peptidome Hla-b*27 Ankylosing spondylitis Erap2 
ProteomicsHLA B-27 rats peptidome - The HLA-B27 peptidome in vivo in spondyloarthritis-susceptible HLA-B27 transgenic rats and the effect of ERAP1 deletion
HLA-B27 is a class I major histocompatibility (MHC-I) allele that confers susceptibility to the rheumatic disease ankylosing spondylitis (AS) by an unknown mechanism. ERAP1 is an aminopeptidase that trims peptides in the endoplasmic reticulum for binding to MHC-I molecules. ERAP1 shows genetic epist...
ORGANISM(S): Rattus norvegicus (Rat) 
2017-02-13 | PXD005502 | Pride
Transgenic rats Hla-b27 Peptidome Ankylosing spondylitis Human leukocytes antigen 
UnknownImmune Checkpoint Blockade Augments Changes Within Oncolytic Virus-induced Cancer MHC-I Peptidome, Creating Novel Antitumor CD8 T Cell Reactivities.
Not available
S-EPMC8864471 | biostudies-literature
UnknownDefective Proinsulin Handling Modulates the MHC I Bound Peptidome and Activates the Inflammasome in β-Cells.
Not available
S-EPMC9024965 | biostudies-literature
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