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ProteomicsSubstantial Influence of ERAP2 on the HLA-B*40:02 peptidome. Implications for HLA-B*27-negative ankylosing spondylitis.
HLA-B*40:02 is one of a few Major Histocompatibility Complex class I (MHC-I) molecules associated with ankylosing spondylitis (AS) independently of HLA-B*27. The endoplasmic reticulum aminopeptidase 2 (ERAP2), an enzyme that process MHC-I ligands and preferentially trims N-terminal basic residues, i...
ORGANISM(S): Homo sapiens (Human) 
2019-09-25 | PXD014804 | Pride
Hla-b*40:02 peptidome Hla-b*27 Ankylosing spondylitis Erap2 
ProteomicsMHC Peptidomics: HLA-B*27 vs Mamu-B*08
Indian rhesus macaques are arguably the most reliable animal models in AIDS research. In this species the MHC class I allele Mamu-B*08, among others, is associated with elite control of SIV replication. A similar scenario is observed in humans where the expression of HLA-B*27 or HLA-B*57 has been li...
ORGANISM(S): Homo sapiens (Human) 
2016-10-07 | PXD004964 | Pride
Peptides Hla-b*27 Mhc Hiv Peptidomics Mamu-b*08 Lc-ms/ms Siv 
ProteomicsHLA-I peptidomes and phosphopeptidomes (B*40, B*27, B*07, B*39)
As aberrant phosphorylation is a hallmark of tumor cells, the display of tumor-specific phosphopeptides by Human Leukocyte Antigen (HLA) class I molecules can be exploited in the treatment of cancer by T-cell-based immunotherapy. Yet, the characterization and prediction of HLA-I phospholigands is ch...
ORGANISM(S): Homo sapiens (Human) 
2016-12-12 | PXD005084 | Pride
Phosphopeptidome Mhc Peptidome Hla 
GenomicsHLA B*54:NEW
HLA B*54:NEW
PRJEB95097 | ENA
ProteomicsIdentification of HLA-B*57:01-restricted endogenous and HIV epitopes
A novel modified HLA-B*57:01-restricted epitope was identified in one of the reversed-phase fractions following immunoaffinity purification of HLA-peptide complexes from C1R cells expressing HIV envelope protein. Also includes six immunopeptidome datasets from several B57 and env transfected cell ly...
ORGANISM(S): HIV-1 M:B_HXB2R Homo sapiens (Human) 
2018-02-19 | PXD004471 | Pride
Hla-b*57:01 Hiv envelope Immunopeptidomics Kynurenine 
ProteomicsIDENTIFICATION OF AN UNCONVENTIONAL SUBPEPTIDOME BOUND TO THE BEHÇET’S DISEASE - ASSOCIATED HLA–B*51:01 THAT IS REGULATED BY ENDOPLASMIC RETICULUM AMINOPEPTIDASE 1 (ERAP1)
Human leukocyte antigen (HLA) - B*51:01 and endoplasmic reticulum aminopeptidase 1 (ERAP1) are two strong predisposing genetic factors to Behçet's disease (BD). Previous studies have focused on two subgroups of HLA-B*51 peptidome containing Proline (Pro) or Alanine (Ala) at position 2 (P2). Little i...
ORGANISM(S): Homo sapiens (Human) 
2020-03-18 | PXD013064 | Pride
Erap1  hla–b*51:01  behçet’s disease 
ProteomicsArginine (di)methylated Human Leukocyte Antigen class I peptides are favorably presented by HLA-B*07
Specific alterations in protein post-translational modification (PTMs) are recognized hallmarks of diseases. These modifications potentially provide a unique disease-related source of Human Leukocyte Antigen (HLA) class I-presented peptide antigens that can elicit specific immune responses. Although...
ORGANISM(S): Homo sapiens (Human) 
2016-08-15 | PXD004233 | Pride
Methylation Dimethylation Ethcd Hla-class i 
ProteomicsRedundancy and Complementarity between ERAP1 and ERAP2 Revealed by their Effects on the Behçet’s Disease-Associated HLA-B*51 Peptidome
The endoplasmic reticulum aminopeptidases ERAP1 and ERAP2 trim peptides to be loaded onto HLA molecules, including the main risk factor for Behçet’s disease HLA-B*51. ERAP1 is also a risk factor among HLA-B*51-positive individuals, whereas no association is known with ERAP2. This study addressed the...
ORGANISM(S): Homo sapiens (Human) 
2019-05-20 | PXD012348 | Pride
Hla-b*51 Erap1 Behçet’s disease Erap2 Peptidome 
ProteomicsWorkingtitle HLA-B*57:01 CBZ EPX impact
Impact of CBZ and EPX treatment on a with HLA-B*57:01 tranduced cell line compared to the parental cell line
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD037502 | Pride
Hla-b*57:01 human hla cbz epx 
GenomicsDetection of an HLA-B*15:56
Detection of an HLA-B*15:56
PRJEB36330 | ENA
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