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TranscriptomicsIncreased antigen cross-presentation but impaired cross-priming after activation of PPARγ
Increased antigen cross-presentation but impaired cross-priming after activation of PPARγ is mediated by up-regulation of B7H1 Dendritic cells (DCs) are able to take up exogenous antigens and present antigen-derived peptides on MHC class I molecules, a process termed cross-presentation. The mannose...
ORGANISM(S): Mus musculus 
2010-05-08 | E-GEOD-15616 | biostudies-arrayexpress
ProteomicsHLA-DO Modulates the Diversity of the MHC-II Self-peptidome
HLA-DR1 bound peptides of five biological replicates of LG2-WT(012916_WT1,022216_WT1, 02080316MHCIIWT1, 080316MHCIIWT2, 080316MHCIIWT3) and DO-KO Clone 1 LG-2 cells (012916_KO1, 022216_DO1, 081216MHCIIKO1, 080416MHCIIKO2, 080416MHCIIKO3) were processed in parallel. Each biological replicate has 3 te...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-07-03 | MSV000082570 | MassIVE
ProteomicsQuantitative Measurement of the Requirement of Diverse Protein Degradation Pathways in MHC Class I Peptide Presentation
The adaptive immune system distinguishes self from non-self by surveying peptides generated from degradation of intracellular proteins that are loaded onto MHC Class I molecules for display on the cell surface. While early studies reported that the bulk of cell surface MHC Class I complexes require ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-02-15 | MSV000091285 | MassIVE
TranscriptomicsTranscription profiling by array of human monocytes were cultured with DcR3 in the presence of M-CSF
Decoy receptor 3 (DcR3) is a member of the TNF receptor superfamily and is up-regulated in tumors that originate from a diversity of lineages. DcR3 is capable of promoting angiogenesis, inducing dendritic cell apoptosis, and modulating macrophage differentiation. Since tumor-associated macrophages (...
ORGANISM(S): Homo sapiens 
2008-04-05 | E-GEOD-10856 | biostudies-arrayexpress
ProteomicsStudy Samples Dendritic Cell MHC II presentation by LC-MSMS
MAPPs data was used to construct an artificial neural network (ANN) model for MHC class II antigen presentation. Using Infliximab and Rituximab, the model demonstrated an unprecedented performance for predicting MAPPs and CD4 T cell epitopes, complementing results from MAPPs assays and outperforming...
ORGANISM(S): Homo sapiens (Human) 
2020-06-24 | PXD018303 | Pride
Lc-msms Mhc-associated peptide proteomics (mapps) Mhc ii presentation Dendritic cells 
ProteomicsMHC class I ligandome of cells treated with palladium
MHC class I ligandome analysis of mouse dendritic cells treated with palladium
ORGANISM(S): Mus Musculus (mouse) 
2021-12-16 | PXD028795 | JPOST Repository
ProteomicsThe Atlantic cod MHC I compartment has the properties needed for cross-presentation in the absence of MHC II
Atlantic cod and codfish (Gadiformes) lack major histocompatibility complex (MHC) class II and CD4+ T cells, components of the immune system that are central to autoimmune diseases and to fight bacterial infections. In mammalians, the MHC class II molecules are expressed in cells of the immune syste...
ORGANISM(S): Gadus morhua (Atlantic cod) 
2025-05-13 | PXD050180 | Pride
Cross-presentation Mhc i Atlantic cod Endosomal pathway 
ProteomicsImmunopeptidomics informs discovery and delivery of Mycobacterium tuberculosis MHC-II antigens for vaccine design
No currently licensed vaccine reliably prevents pulmonary tuberculosis, a leading cause of infectious disease mortality with a growing rate of extensive drug resistance. Developing effective new vaccines will likely require identifying Mycobacterium tuberculosis (Mtb)-derived antigens presented on M...
ORGANISM(S): Homo sapiens (Human) 
2025-09-18 | PXD055952 | Pride
Dendritic cells Tuberculosis Mhc class ii Human Immunopeptidomics 
TranscriptomicsTranscription profiling of mouse dendritic subsets in vivo
Dendritic cells (DCs) process and present self and foreign antigens to induce tolerance or immunity. In vitro models suggest that induction of immunity is controlled by regulating the presentation of antigen, but little is known about how DCs control antigen presentation in vivo. To examine antigen ...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6259 | biostudies-arrayexpress
ProteomicsBlood leukocytes recapitulate diabetogenic peptide-MHC-II complexes displayed in the pancreatic islets
Assessing the self-peptides presented by susceptible major histocompatibility complex (MHC) molecules is crucial for evaluating the pathogenesis and therapeutics of tissue-specific autoimmune diseases. However, direct examination of such MHC-bound peptides displayed in the target organ remains large...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-26 | PXD024400 | Pride
Blood leukocytes Nod mouse Mhc-ii peptidome 
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