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ProteomicsHLA-DO Modulates the Diversity of the MHC-II Self-peptidome
HLA-DR1 bound peptides of five biological replicates of LG2-WT(012916_WT1,022216_WT1, 02080316MHCIIWT1, 080316MHCIIWT2, 080316MHCIIWT3) and DO-KO Clone 1 LG-2 cells (012916_KO1, 022216_DO1, 081216MHCIIKO1, 080416MHCIIKO2, 080416MHCIIKO3) were processed in parallel. Each biological replicate has 3 te...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-07-03 | MSV000082570 | MassIVE
ProteomicsProteomic identification of MHC class I-associated peptidome derived from non-obese diabetic mouse thymus and pancreas
The peptides repertoire presented to CD8+ T cells by major histocompatibility complex (MHC) class I molecules, referred to as the MHC I-associated peptidome (MIP), regulates all critical events that occur during the lifetime of CD8+ T cells. The MIP presented by thymic antigen presenting cells (APCs...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-14 | PXD031966 | Pride
Pancreas Lc-ms/ ms Nod mouse Mhc class i-associated peptidome T1d Cd8+ t-cell. Thymus 
ProteomicsThe pancreatic islet MHC-II peptidome identifies key features of autoimmune peptides
The nature of autoantigens that trigger autoimmune diseases has been much discussed but direct biochemical identification is lacking for most. Addressing this question demands unbiased examination of the self-peptides displayed by a defined autoimmune MHC-II molecule. We have examined the immunopept...
ORGANISM(S): Mus musculus (Mouse) 
2020-03-12 | PXD015408 | Pride
Hybrid insulin peptides Pln Mhc-ii peptidome Nod mouse Islets Spleen 
GenomicsMHC-II peptidome of the CNS reveals endogenous guardian peptides
MHC-II peptidome of the CNS reveals endogenous guardian peptides
PRJNA1004626 | ENA
ProteomicsThe effect of proteasome inhibition on the HLA peptidome
The Major histocompatibility complex (MHC) class I peptidome is thought to be generated mostly through proteasomal degradation of cellular proteins, a notion that is based on the alterations in presentation of selected peptides following proteasome inhibition. We evaluated the effects of proteasome ...
ORGANISM(S): Homo sapiens (Human) 
2018-11-27 | PXD000171 | Pride
Hla peptidome Proteasome inhibitors Dynamic silac 
ProteomicsIntegrative MHC-I peptidome quantitation with isobaric tagging mass spectrometry
Despite the appreciation of CD8+ T cell anti-tumor immune responses towards improvement patient outcomes, the MHC-I peptides that facilitate the response are poorly described. Alternatively, whether cancer therapies alter the MHC-I peptide repertoire has not been fully assessed due to the lack of qu...
ORGANISM(S): Homo sapiens (Human) 
2019-03-05 | PXD011464 | Pride
Mhc-i peptidomics Source proteome 
ProteomicsIntegrative MHC-I peptidome quantitation with isobaric tagging mass spectrometry
Despite the appreciation of CD8+ T cell anti-tumor immune responses towards improvement patient outcomes, the MHC-I peptides that facilitate the response are poorly described. Alternatively, whether cancer therapies alter the MHC-I peptide repertoire has not been fully assessed due to the lack of qu...
ORGANISM(S): Mus musculus (Mouse) 
2019-03-05 | PXD011444 | Pride
Source proteins Mhc-i peptides 
ProteomicsNNAlign_MA; MHC peptidome deconvolution for accurate MHC binding motif characterization and improved T cell epitope predictions
Current mass spectrometry technologies allow for identification of MHC-associated peptide ligands. Studies have proven these data to be a rich source of information for learning the rules of MHC-mediated antigen presentation. Such immunopeptidomes are usually poly-specific, containing multiple seque...
ORGANISM(S): Bos taurus (Bovine) 
2019-10-07 | PXD015240 | Pride
Immunopeptidomics Bola ligandome 
UnknownThe MHC-II peptidome of pancreatic islets identifies key features of autoimmune peptides.
Not available
S-EPMC7117798 | biostudies-literature
TranscriptomicsTranscription profiling of dendritic cells derived from the bone marrow of wild type and Lmp7-/-Mecl1-/- mice
Comparison of the MHC I peptidome and of the transcriptome of dendritic cells derived from WT and Lmp7-/-Mecl1-/- mice bone marrow
ORGANISM(S): Mus musculus 
2010-07-22 | E-TABM-750 | biostudies-arrayexpress
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