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ProteomicsHLA-DO Modulates the Diversity of the MHC-II Self-peptidome
HLA-DR1 bound peptides of five biological replicates of LG2-WT(012916_WT1,022216_WT1, 02080316MHCIIWT1, 080316MHCIIWT2, 080316MHCIIWT3) and DO-KO Clone 1 LG-2 cells (012916_KO1, 022216_DO1, 081216MHCIIKO1, 080416MHCIIKO2, 080416MHCIIKO3) were processed in parallel. Each biological replicate has 3 te...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-07-03 | MSV000082570 | MassIVE
ProteomicsThe pancreatic islet MHC-II peptidome identifies key features of autoimmune peptides
The nature of autoantigens that trigger autoimmune diseases has been much discussed but direct biochemical identification is lacking for most. Addressing this question demands unbiased examination of the self-peptides displayed by a defined autoimmune MHC-II molecule. We have examined the immunopept...
ORGANISM(S): Mus musculus (Mouse) 
2020-03-12 | PXD015408 | Pride
Hybrid insulin peptides Pln Mhc-ii peptidome Nod mouse Islets Spleen 
GenomicsMHC-II peptidome of the CNS reveals endogenous guardian peptides
MHC-II peptidome of the CNS reveals endogenous guardian peptides
PRJNA1004626 | ENA
ProteomicsBlood leukocytes recapitulate diabetogenic peptide-MHC-II complexes displayed in the pancreatic islets
Assessing the self-peptides presented by susceptible major histocompatibility complex (MHC) molecules is crucial for evaluating the pathogenesis and therapeutics of tissue-specific autoimmune diseases. However, direct examination of such MHC-bound peptides displayed in the target organ remains large...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-26 | PXD024400 | Pride
Blood leukocytes Nod mouse Mhc-ii peptidome 
UnknownThe MHC-II peptidome of pancreatic islets identifies key features of autoimmune peptides.
Not available
S-EPMC7117798 | biostudies-literature
UnknownHLA-DO Modulates the Diversity of the MHC-II Self-peptidome.
Not available
S-EPMC6398211 | biostudies-literature
ProteomicsMHC-II peptidome of the CNS reveals endogenous guardian peptides
Mass spectrometry analysis of MHC-II peptidomes from several central nervous system tissues in mice.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-08-11 | MSV000092643 | MassIVE
UnknownThe Dendritic Cell Major Histocompatibility Complex II (MHC II) Peptidome Derives from a Variety of Processing Pathways and Includes Peptides with a Broad Spectrum of HLA-DM Sensitivity.
Not available
S-EPMC4786700 | biostudies-literature
TranscriptomicsMHC-II peptidome of the CNS reveals endogenous guardian peptides
The central nervous system (CNS), despite the presence of strategically positioned anatomical barriers designed to protect it, is not entirely isolated from the immune system. In fact, it remains physically connected to and can be influenced by the peripheral immune system. How the CNS retains such ...
ORGANISM(S): Mus musculus 
2024-10-11 | GSE240691 | GEO
ProteomicsCharacterization of I-Ab MHCII immunopeptidome eluted from control and obese (Ob/Ob) mice using a combination of data-dependent (DDA) and data-independent acquisition (DIA) nanoLC mass spectrometry
In Dendritic cells (DC), the MHC II eluted immunopeptidome reflects the antigenic composition of the microenvironment. Proteins are transported and processed into peptides in endosomal MHC II compartments through autophagy or phagocytosis; extracellular peptides can also directly bind MHC II protein...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-21 | PXD023581 | Pride
Mouse dendritic cells  i-ab mhc-ii immunopeptidome  dda and dia nanolcms 
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