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Dysregulated kinase activity drives oncogenic signalling, perturbs cellular homeostasis, and promotes tumour progression. Despite major success in targeting kinases therapeutically, the downstream consequences of kinase inhibition and the mechanisms underlying drug resistance remain incompletely ...

2025-12-09 | MTBLS7390 | MetaboLights
This project probes E. coli natural proteins that bind to a de novo protein Resc4.
ORGANISM(S): Escherichia coli 
2026-08-05 | PXD076206 | Pride
Chemical Denaturation and Protein Precipitation (CPP) was performed on an E. coli lysate in order to determine the precipitaiton midpoint for the proteome
ORGANISM(S): Escherichia coli 
2023-01-03 | PXD036219 | Pride
Apolipoprotein E (apoE) is a 317-amino-acid long glycoprotein with three common isoforms (apoE2, apoE3, and apoE4) encoded by three apoE alleles (ε2, ε3, and ε4). These polymorphic forms arise from single amino acid substitutions with Cys and Arg interchanged at positions 112 and 158 (mature protein...
ORGANISM(S): Homo Sapiens 
To probe the thermodynamic stability of proteins within the E. coli proteome through proteomic technique SPROX.
ORGANISM(S): Escherichia coli 
2023-01-03 | PXD035834 | Pride
Mouse EMT6 breast cancer cells were grown in 3D Matrigel culture. Effects of the glycosaminoglycan chondroitin sulfate-E (CS-E) versus untreated controls on transcriptional programs was investigated.
ORGANISM(S): Mus musculus 
Using a range of copper we have utilized Metal-induced Protein Precipitaiton (MiPP) technique to elucidate the copper midpoints of the proteins found in an E. coli proteome. Using bottem-up proteomics techniques and TMT-10 plex isobaric mass-tags we were able to use MiPP to classify proteins based o...
ORGANISM(S): Escherichia coli 
2023-01-03 | PXD035711 | Pride
This project probes the effect of mutations on a de novo life-sustaining protein Resc4 to the soluble and insoluble proteome of E. coli delta metC cells.
ORGANISM(S): Escherichia coli 
2026-08-05 | PXD079835 | Pride
We used RNA-seq to determine the effects of AraC and arabinose on RNA levels genome-wide in S. enterica. Wild-type or delta araC mutant cells were grown in both the presence and absence of 0.2% L-arabinose. RNA-Seq libraries from two independent biological replicate samples were sequenced for (i) wi...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium str. 14028s Wu 
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