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ProteomicsPKR activity modulation by phosphomimetic mutations of serine residues located three aminoacids upstream of double-stranded RNA binding motifs
Eukaryotic translation initiation factor 2 alpha kinase 2 (EIF2AK2), better known as PKR plays a key role in the response to viral infections and cellular homeostasis by regulating mRNA translation. Upon binding dsRNA, PKR is activated through homodimerization and subsequent autophosphorylation on T...
ORGANISM(S): Homo sapiens (Human) 
2021-05-10 | PXD022564 | Pride
Dsrna binding Viral infection Pkr Autophosphorylation Regulation 
ProteomicsIdentification of RSK substrates using an analog-sensitive kinase approach
RSK1 and RSK4 are two of the four members of the p90 ribosomal protein S6 kinases (RSK) family. These kinases are downstream kinases of mitogen-activated protein kinase 1 (ERK or MAPK1) in the ERK MAP kinase pathway. RSKs are implicated in fine tuning of cellular processes such as translation, trans...
ORGANISM(S): Homo sapiens (Human) 
2024-02-06 | PXD047020 | Pride
Rsk1 Rsk4 Mapk pathway Kinase Substrate 
ProteomicsCardiovirus-Mediated PKR Inhibition Results from Nucleocytoplasmic Trafficking Disruption
Protein kinase R (PKR) is a key antiviral kinase activated by binding double-stranded RNA (dsRNA) produced during viral replication. Upon activation, PKR phosphorylates eIF2α, leading to the inhibition of translation and viral replication. However, many viruses have evolved mechanisms to counteract ...
ORGANISM(S): Homo sapiens (Human) 
2025-11-17 | PXD066206 | Pride
Nucleocytoplasmic traffic Pkr Nucleocytoplasmic trafficking disorder (nctd) Cardiovirus Stress granules. Picornavirus Nucleoli Double-stranded rna Eif2ak2 
ProteomicsCardioviruses’ leader proteins retarget RSK kinases toward alternative substrates to perturb nucleocytoplasmic traffic
Proteins from unrelated pathogens, including some RNA or DNA viruses and bacteria can recruit and activate cellular p90-ribosomal protein S6 kinases (RSKs) through a common linear motif. Data suggested a model where pathogens' proteins act to dock the recruited RSKs toward specific substrates, which...
ORGANISM(S): Homo sapiens (Human) 
2022-12-08 | PXD034604 | Pride
P90 ribosomal s6 kinases Picornavirus Nucleocytoplasmic traffic Rsk Cardiovirus Phosphorylation Yopm Nucleoporins Linear motifs 
TranscriptomicsGene expression after type-I interferon treatment in primary neurons, primary fibroblasts and L929 cells
Microarray expression profilling of mouse primary mixed cortical/hippocampal neurons, primary fibroblasts and L929 cells to compare ISGs signature in disctinct cell types Primary mixed cortical/hippocampal neurons, primary fibroblasts (MEFs) and L929 cells were mock-treated or treated with 5U/mL of ...
ORGANISM(S): Mus musculus 
2014-01-10 | E-GEOD-53951 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of breast cancer distant metastasis based on outcome over time and identification of pathway activities of late relapse
Previous reports have described the use of microarrays to assess the molecular classification of human breast cancers and defined new subgroups based on gene expression that are relevant to patient management through their ability to predict metastatic relapse and survival relapse. However, differen...
ORGANISM(S): Homo sapiens 
2013-08-01 | E-MTAB-949 | biostudies-arrayexpress
UnknownIndividual Participant Data Network Meta-Analysis of Neoadjuvant Chemotherapy or Chemoradiotherapy in Esophageal or Gastroesophageal Junction Carcinoma.
Not available
S-EPMC10553121 | biostudies-literature
UnknownSubgroup-specific structural variation across 1,000 medulloblastoma genomes.
Not available
S-EPMC3683624 | biostudies-literature
UnknownIn-hospital and 6-month outcomes in patients with COVID-19 supported with extracorporeal membrane oxygenation (EuroECMO-COVID): a multicentre, prospective observational study.
Not available
S-EPMC9671669 | biostudies-literature
UnknownThe tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group.
Not available
S-EPMC8636568 | biostudies-literature
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