Sort   by:  
 Page size 
TranscriptomicsDefining the microglia transcriptome in multifunctional protein-2 deficient mice
Purpose: We purified whole brain microglia of MFP2 knockout mice and control mice utilizing percoll gradient and FACS sorting, followed by microarray analysis to define the molecular changes in MFP2 knockout mice at the endstage of the disease. We compared the microglia transcriptome of Mfp2-/- micr...
ORGANISM(S): Mus musculus 
2015-04-14 | E-GEOD-66420 | biostudies-arrayexpress
TranscriptomicsExpression data from amoeboid and ramified microglia isolated from the corpus callosum of 5-day and 4-week old rat brain
Microglia, the resident immune cells of the central nervous system (CNS), have two distinct phenotypes in the developing brain: amoeboid form, known to be amoeboid microglial cells (AMC) and ramified form, known to be ramified microglial cells (RMC) alongside several intermediate forms. The AMC are ...
ORGANISM(S): Rattus norvegicus 
2011-06-11 | E-GEOD-29885 | biostudies-arrayexpress
TranscriptomicsIn vivo response of microglia to Aβ and prostaglandin-E2 EP2 receptor signaling
Microglia, the innate immune cells of the central nervous system, perform critical inflammatory and non-inflammatory functions to maintain homeostasis and normal neural function. However in Alzheimer’s disease (AD), these beneficial functions become progressively impaired, contributing to synapse a...
ORGANISM(S): Mus musculus 
2015-02-20 | E-GEOD-57181 | biostudies-arrayexpress
GenomicsMutant Huntingtin promotes neuronal death through cell autonomous microglial activation via myeloid lineage- determining factors
Huntington's Disease (HD) is a fatal neurodegenerative disorder caused by an extended polyglutamine repeat in the N-terminus of the huntingtin (Htt) protein. Reactive microglia and elevated cytokine levels are observed in the brains of HD patients, but the extent to which neuroinflammation results f...
ORGANISM(S): Mus musculus 
2014-03-02 | E-GEOD-54443 | biostudies-arrayexpress
TranscriptomicsIntegrated expression profiles of mRNA and miRNA in polarized primary murine microglia (miRNA)
The aim of this study was to determine the role that miRNAs have on influencing murine microgial phenotypes under M1(LPS) and M2a (IL-4) stimulating conditions. This Series includes expression data obtained from miRNA gene expression microarrays; mRNA expression profiles obtained from the same RNA s...
ORGANISM(S): Mus musculus 
2014-03-13 | E-GEOD-49330 | biostudies-arrayexpress
TranscriptomicsIntegrated expression profiles of mRNA and miRNA in polarized primary murine microglia (mRNA)
The aim of this study was to determine the role that miRNAs have on influencing murine microgial phenotypes under M1(LPS) and M2a (IL-4) stimulating conditions. This Series includes expression data obtained from mRNA gene expression microarrays; miRNA expression profiles obtained from the same RNA s...
ORGANISM(S): Mus musculus 
2014-03-13 | E-GEOD-49329 | biostudies-arrayexpress
TranscriptomicsDefining the microglia transcriptome during disease progression in ALS transgenic mice
Purpose: We purified spinal cord microglia utilizing percoll gradients and magnetic beads, followed by transcriptome profiling (RNA-seq) to define microglia expression profiles against other neural, immune cell-types. We next observed how the microglial transcriptomes change during activation in the...
ORGANISM(S): Mus musculus 
2013-07-15 | E-GEOD-43366 | biostudies-arrayexpress
TranscriptomicsAcutely isolated murine cortical astrocytes and microglia: Alzheimer's disease vs wildtype
Isolation of glia from Alzheimer's mice reveals inflammation and dysfunction. Reactive astrocytes and microglia are associated with amyloid plaques in Alzheimer's disease (AD). Yet, not much is known about the molecular alterations underlying this reactive phenotype. To get an insight into the mole...
ORGANISM(S): Mus musculus 
2015-11-04 | E-GEOD-74615 | biostudies-arrayexpress
TranscriptomicsAcutely isolated murine cortical astrocytes and microglia: Alzheimer's disease vs wildtype- effect of gfap-/- and vim-/-
GFAP and vimentin deficiency alters gene expression in astrocytes and microglia in wild-type mice and changes the transcriptional response of reactive glia in mouse model for Alzheimer's disease. Reactive astrocytes with an increased expression of intermediate filament (IF) proteins Glial Fibrillary...
ORGANISM(S): Mus musculus 
2015-11-04 | E-GEOD-74614 | biostudies-arrayexpress
TranscriptomicsExpression data from maternally inflamed and Dap12-mutant microglia at E17.5.
Microglia colonize the brain parenchyma at early stages of development and accumulate in specific regions where they actively participate in cell death, angiogenesis, neurogenesis and synapse elimination. A recurring feature of embryonic microglial distribution is their association with developing a...
ORGANISM(S): Mus musculus 
2014-07-01 | E-GEOD-49079 | biostudies-arrayexpress
Sort   by:  
 Page size