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MetabolomicsDistinct lipid signatures are identified in the plasma of rats with chronic inflammation induced by estradiol benzoate and sex hormones

INTRODUCTION: Prostatitis is likely to occur in younger or middle-aged men, while prostate cancer is likely to occur in older men. Although amino acids and lipids as biomarkers of prostate cancer have been examined using prostate cancer cell lines/tissues, no previous studies hav...

2020-11-04 | MTBLS2028 | MetaboLights
TranscriptomicsIdentification of new therapeutic targets by genome-wide analysis of gene expression in the ipsilateral cortex of aged rats after stroke
Because most human stroke victims are elderly, studies of experimental stroke in the aged rather than the young rat model may be optimal for identifying clinically relevant cellular responses, as well for pinpointing beneficial interventions. We employed the Affymetrix platform to analyze the whole-...
ORGANISM(S): Rattus norvegicus 
2014-04-22 | E-GEOD-55260 | biostudies-arrayexpress
ProteomicsRat colon LC-MSMS - Intake of Fish Oil Specifically Modulates Colonic Muc2 Expression in Middle-Aged Rats by Suppressing the Glycosylation Process
Dietary fats have been shown to affect gut microbiota composition and aging gene transcription of middle-aged rats at a normal dose, but little is known about such an effect on gut barrier. In colon, the main component of mucus layer is Muc2, produced by the goblet cells. This study investigated the...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-01-02 | PXD007229 | Pride
Lc-msms Rat Colon 
TranscriptomicsTo examine the influence of the early stress of maternal separation on the hippocampal transcriptome in middle-aged life
In this study, we examined the consequences of the early stress (ES) of maternal separation on hippocampal gene expression in middle-aged animals. Middle-aged (15 months old) ES animals exhibit hippocampal transcriptome changes with a significant regulation of genes associated with ion binding, tran...
ORGANISM(S): Rattus norvegicus 
2013-10-11 | E-GEOD-29414 | biostudies-arrayexpress
MetabolomicsLocal and systemic metabolic alterations in brain, plasma, and liver of rats in response to aging and ischemic stroke, as detected by nuclear magnetic resonance (NMR) spectroscopy
Cerebral ischemia and aging induce local and systemic effects, and impact severity of stroke outcome. We performed comprehensive metabolic profiling to detect metabolites in brain, plasma, and liver as a function of aging and ischemia/reperfusion (IR). Ischemic stroke was induced by middle cerebral ...
2019-02-01 | MTBLS516 | MetaboLights
GenomicsThe PKC-β selective inhibitor, Enzastaurin, impairs memory in middle-aged rats
The PKC-β selective inhibitor, Enzastaurin, impairs memory in middle-aged rats
PRJNA451011 | ENA
ProteomicsQuantification of glycated rat serum albumin peptides
Serum albumin is the most abundant plasma protein with a large number of lysine and arginine residues. Hence, it is highly susceptible to glycation, a non-enzymatic reaction involving binding of non-reducing sugars to proteins, in vivo. Oxidative stress is known to promote glycation and the Advanced...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-06-29 | PXD074495 | Pride
Glycation Swath-mass spectrometry Serum Albumin peptides Middle-aged rats 
UnknownDiabetes Mellitus Impairs Cognitive Function in Middle-Aged Rats and Neurological Recovery in Middle-Aged Rats After Stroke.
Not available
S-EPMC4961558 | biostudies-literature
TranscriptomicsTranscription profiling by array of hippocampal regions CA1, CA3, and DG from aged, calorically restricted rats
Aging is associated with a decline in hippocampal mediated learning and memory, a process which can be ameliorated by dietary (caloric) restriction. We used Affymetrix gene expression analysis to monitor changes in three regions of the hippocampus (CA1, CA3, DG) of middle aged (18 months) and old (2...
ORGANISM(S): Rattus norvegicus 
2010-06-08 | E-GEOD-21681 | biostudies-arrayexpress
GenomicsExpression data from the cortex after middle cerebral artery occlusion (MCAO) between young and aged rats
Expression data from the cortex after middle cerebral artery occlusion (MCAO) between young and aged rats
PRJNA699509 | ENA
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