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GenomicsERa-dependent E2F transcription can mediate resistance to estrogen deprivation in human breast cancer
This SuperSeries is composed of the following subset Series: GSE22533: Breast cancer cells resistant to hormone deprivation maintain an estrogen receptor alpha-dependent, E2F-directed transcriptional program GSE27300: Estrogen-independent genomic ER binding analysis Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-05-14 | E-GEOD-37955 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of breast cancer subtypes are detectable in histologically normal breast epithelium
Background: We hypothesize that important genomic differences between breast cancer subtypes occur early in carcinogenesis. Therefore, gene expression might distinguish histologically normal breast epithelium (NlEpi) from breasts containing estrogen receptor positive (ER+) compared with estrogen rec...
ORGANISM(S): Homo sapiens 
2010-12-07 | E-GEOD-21947 | biostudies-arrayexpress
TranscriptomicsBreast cancer cells resistant to hormone deprivation maintain an estrogen receptor alpha-dependent, E2F-directed transcriptional program
A significant fraction of breast cancers exhibit de novo or acquired resistance to estrogen deprivation. To model resistance to aromatase inhibitor (AI) therapy, long-term estrogen-deprived (LTED) derivatives of MCF-7 and HCC-1428 cells were generated through culture for 3 and 7 months under hormone...
ORGANISM(S): Homo sapiens 
2012-05-13 | E-GEOD-22533 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of estrogen receptor positive breast cancer cell lines after long term estrogen deprivation
Hyperactivation of phosphatidylinositol-3 kinase (PI3K) promotes escape from hormone dependence in estrogen receptor-positive breast cancer. A significant fraction of breast cancers exhibit de novo or acquired resistance to estrogen deprivation. We used gene expression microarrays to identify genes...
ORGANISM(S): Homo sapiens 
2010-06-23 | E-GEOD-19639 | biostudies-arrayexpress
ProteomicsRPA70 interactors in BJ and BJ RAS
Activation of oncogenes in healthy cells leads to a permanent cell cycle arrest termed oncogene-induced senescence (OIS) characterized by increased DNA damage and deep epigenetic resetting. Bypassing this premalignant state promotes tumorigenesis. Here, we show that cells entering OIS accumulate hig...
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD060652 | Pride
Senescence Rpa70 Rnaseh1 R-loop 
MetabolomicsLipid biomarkers for algal resistance to viral infection in the ocean

Marine viruses play a key role in regulating phytoplankton populations, greatly affecting the biogeochemical cycling of major nutrients in the ocean. Resistance to viral infection has been reported for various phytoplankton species under laboratory conditions. Nevertheless, the occurrence of resi...

2023-06-12 | MTBLS3323 | MetaboLights
UnknownAutophagy promotes escape from phosphatidylinositol 3-kinase inhibition in estrogen receptor-positive breast cancer.
Not available
S-EPMC5892720 | biostudies-literature
UnknownMutations in the ER-shaping protein reticulon 2 cause the axon-degenerative disorder hereditary spastic paraplegia type 12.
Not available
S-EPMC3266795 | biostudies-literature
UnknownEstrogen Therapy Induces Receptor-Dependent DNA Damage Enhanced by PARP Inhibition in ER+ Breast Cancer.
Not available
S-EPMC10528687 | biostudies-literature
UnknownPET/MRI of hypoxia and vascular function in ER-positive breast cancer: correlations with immunohistochemistry.
Not available
S-EPMC10415421 | biostudies-literature
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