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MetabolomicsRecombinant Production of Biliverdin IXβ and δ Isomers in the T7 Promoter Compatible Escherichia coli Nissle
The ability to obtain purified biliverdin IX (BVIX) isomers other than the commercially available BVIXα is limited due to the low yields obtained by the chemical coupled oxidation of heme. Chemical oxidation requires toxic chemicals, has very poor BVIX yields (<0.05%), and is not conducive to scalab...
2021-12-16 | MTBLS3555 | MetaboLights
TranscriptomicsFriends not foes: CTLA-4 blockade and mTOR inhibition cooperate during CD8+ T cell priming
T cells receive numerous positive and negative signals during primary antigen encounter that control their proliferation and function, but how these signals are integrated to modulate T cell memory has not been fully characterized. In these studies, we demonstrate that combining seemingly opposite ...
ORGANISM(S): Mus musculus 
2015-01-31 | E-GEOD-63022 | biostudies-arrayexpress
TranscriptomicsExpression data from OT-I CD8 T cells activated with DC in the presence or absence of CpG-Induced Inflammation
Inflammatory cytokines promote the accumulation of activated CD8 T cells. Here, we transfer 600 OT-I CD8 T cells iv into naïve C57BL/6 hosts. One day later, 500,000 LPS-matured and OVA257 peptide-coated DC were injected iv into OT-I CD8 T cell seeded hosts with (DC+CpG) or without (DC). Other se...
ORGANISM(S): Mus musculus 
2013-12-10 | E-GEOD-53200 | biostudies-arrayexpress
TranscriptomicsId2 and Id3 maintain the regulatory T cell pool to suppress inflammatory disease
Regulatory T (Treg) cells suppress the development of inflammatory disease, but our knowledge of transcriptional regulators that control this function remains incomplete. Here we show that expression of Id2 and Id3 in Treg cells was required to suppress development of fatal inflammatory disease. We ...
ORGANISM(S): Mus musculus 
2014-06-29 | E-GEOD-57682 | biostudies-arrayexpress
ProteomicsIntegrative Network Analysis Reveals USP7 Haploinsufficiency Inhibits E-protein Activity in Pediatric T-lineage Acute Lymphoblastic Leukemia (T-ALL)
USP7, which encodes a deubiquitylating enzyme, is among the most frequently mutated genes in pediatric T-ALL, with somatic heterozygous loss-of-function mutations (haploinsufficiency) predominantly affecting the subgroup that has aberrant TAL1 oncogene activation. Network analysis of >200 T-ALL tran...
ORGANISM(S): Homo sapiens (Human) 
2021-03-16 | PXD023377 | Pride
Tal1 T-all Usp7 
TranscriptomicsTranscription profiling of human blood leukocytes and T-cells
Monitoring genome-wide, cell-specific responses to human disease, although challenging, holds great promise for medicine’s future. Patients with injury severe enough to develop multiple organ dysfunction syndrome (MODS) are known to have multiple immune derangements, including T-cell apoptosis an...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-5580 | biostudies-arrayexpress
ProteomicsMouse T-cell LC-MSMS from WT and MTDH KO
This study uncovers host Metadherin (MTDH) as a pivotal regulator of systemic tumor progression, orchestrating liver metabolism and CD8⁺ T cell immunity. Tumor-derived extracellular vesicles prompt Kupffer cells to release TNFα and TGF-β, which, through MTDH-driven NF-κB signaling, suppress hepatic ...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-29 | PXD064796 | Pride
Mouse Timstof ultra Tumor T-cell 
ProteomicsThe EZH2 inhibitor tazemetostat mitigates HIV immune evasion, reduces reservoir formation, and promotes durable CD8⁺ T-cell revitalization
Persistent HIV reservoirs in CD4⁺ T-cells impede efforts to cure HIV infection. We identified overexpression of enhancer of zeste homolog 2 (EZH2) in HIV-infected CD4⁺ T-cells that survive cytotoxic T lymphocyte (CTL) exposure, suggesting a mechanism of CTL resistance. Inhibition of EZH2 with the FD...
ORGANISM(S): Homo sapiens (Human) 
2026-01-26 | PXD061146 | Pride
Hiv Cd8 t cells Ezh2 Tazemetostat 
GenomicsGabriella Miller Kids First Pediatric Research Program in Pediatric T-cell Acute Lymphoblastic Leukemia
Gabriella Miller Kids First Pediatric Research Program in Pediatric T-cell Acute Lymphoblastic Leukemia
PRJNA871026 | ENA
GenomicsGabriella Miller Kids First Pediatric Research Program in Pediatric T-cell Acute Lymphoblastic Leukemia
Gabriella Miller Kids First Pediatric Research Program in Pediatric T-cell Acute Lymphoblastic Leukemia
PRJNA669323 | ENA
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