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MetabolomicsBiochemical changes in Robinia pseudoacacia leaflets in dependence of leaf mining, plant age and location

Plant responses to leaf-mining insects are still poorly studied, especially in woody species. Robinia pseudoacacia is widely cultivated in Ukraine, where it is not native. There, the trees are facing increasing damage from the likewise introduced leaf miner species Parectopa robiniel...

2026-03-20 | MTBLS14099 | MetaboLights
MetabolomicsFatty acid transport protein 4 is required for incorporation of saturated ultralong-chain fatty acids into epidermal ceramides and monoacylglycerols
Fatty acid transport protein 4 (FATP4) is an acyl-CoA synthetase that is required for normal permeability barrier in mammalian skin. FATP4 (SLC27A4) mutations cause ichthyosis prematurity syndrome, a nonlethal disorder. In contrast, Fatp4-/- mice die neonatally from a defective barrier. H...
2021-07-15 | MTBLS1138 | MetaboLights
ProteomicsInherited C-terminal TREX1 variants disrupt homology-directed repair to cause senescence and DNA damage phenotypes in Drosophila, mice, and humans
Age-related microangiopathy, also known as small vessel disease (SVD), causes damage to the liver, brain, kidney and retina. Based on the DNA damage theory of aging, we reasoned that genomic instability may underlie an SVD caused by dominant C-terminal variants in TREX1, the most abundant 3’-5’ DNA ...
ORGANISM(S): Homo sapiens (Human) 
2024-05-30 | PXD051905 | Pride
Brca1 Retinal vasculopathy with cerebral leukoencephalopathy Cerebroretinal vasculopathy Rvcl-s Rvcl Trex1 Interferon Inflamm-aging Herns Crv Dementia Dna damage response Small vessel disease Vasculopathy 
MetabolomicsIsotope Labeled Reactivity-Based Metabolomics Reveal Cysteine as a Potent In Vivo Scavenger of Lactoylglutathione

Metabolite adducts are increasingly being recognized as important intermediates in cellular metabolism and as circulating messengers. Methylglyoxal (MG) is a highly reactive metabolite involved in diabetes and aging, via formation of a wide variety of protein adducts. Though new types of protein ...

2025-04-29 | MTBLS6287 | MetaboLights
ProteomicsAnammox enrichment culture glycoproteomics
The physiology of the planctomycetal anammox bacteria makes them particularly special because they share features with all three domains of life. Anammox bacteria have been reported recently to produce surface-layer proteins, which represent the outermost layer and provide structure, shape and prote...
ORGANISM(S): Candidatus Kuenenia stuttgartiensis Candidatus Brocadia sapporoensis 
2021-08-05 | PXD021600 | Pride
Mass binning Microbial glycoproteomics Anammox bacteria Metaproteomics 
UnknownMisdirected yet intact TREX1 exonuclease activity causes human cerebral and systemic small vessel disease.
Not available
S-EPMC12316019 | biostudies-literature
UnknownCan additional patient experience items improve the reliability of and add new domains to the CAHPS hospital survey?
Not available
S-EPMC2613993 | biostudies-literature
UnknownCmC(A/T)GG DNA methylation in mature B cell lymphoma gene silencing.
Not available
S-EPMC56973 | biostudies-literature
UnknownAssessing the impacts of mitigation and geoengineering intervention scenarios on Earth system dynamics and climatological variability with multimodal simulations.
Not available
S-EPMC11891324 | biostudies-literature
TranscriptomicsTranscription profiling of mesenchymal stem cells to produce a signature for MSC
Background. The in vivo distribution status and molecular signature of bone marrow mesenchymal stem cells (MSC) remain unknown, although ex vivo expanded MSC have been used in numerous studies. Methods/Results. To address these issues, we identified human MSC-characteristic genes, including 9 transc...
ORGANISM(S): Homo sapiens 
2008-11-13 | E-GEOD-9451 | biostudies-arrayexpress
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