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Proteomics2018CHPP - Digging for Missing Proteins Using Low-Molecular-Weight Protein Enrichment and a "Mirror Protease" Strategy
ABSTRACT Since 2012, Chromosome-Centric Human Proteome Project (C-HPP) launched the journey of missing proteins (MPs) investigation for completing human proteome project (HPP). We found the majority of MPs were distributed in low molecular weight (LMW) ranges, especially in 0-40 kDa. The identificat...
ORGANISM(S): Homo sapiens (Human) 
2018-10-04 | PXD010093 | Pride
Testis Low molecular weight Chromosome-centric human proteome project Mirror-protease Missing proteins 
Proteomics2018CHPP
ABSTRACT Since 2012, Chromosome-Centric Human Proteome Project (C-HPP) launched the journey of missing proteins (MPs) investigation for completing human proteome project (HPP). We found the majority of MPs were distributed in low molecular weight (LMW) ranges, especially in 0-40 kDa. The identificat...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-06-14 | MSV000083978 | MassIVE
ProteomicsMirror-image trypsin digestion and sequencing of D-proteins
The development of mirror-image biology systems and related applications is hindered by the lack of effective methods to sequence mirror-image (D-) proteins. Although natural-chirality (L-) proteins can be sequenced by bottom–up liquid chromatography–tandem mass spectrometry (LC–MS/MS), the sequenci...
ORGANISM(S): Escherichia coli 
2024-01-19 | PXD046228 | Pride
Total chemical synthesis D-trypsin D-protein sequencing Mirror-image biology Lc-ms/ms 
TranscriptomicsConvergent evolution of peptide-based quorum sensing required for virulence in a eukaryotic pathogen
Bacterial quorum sensing (QS) systems are characterized by the regulated biogenesis and sensing of specialized signaling molecules. Here, we describe a peptide, Qsp1, secreted by the fungal pathogen Cryptococcus neoformans. Mutants lacking Qsp1 are attenuated for infection, pulmonary accumulation, a...
ORGANISM(S): Cryptococcus neoformans 
2016-06-08 | GSE73203 | GEO
UnknownPrecision De Novo Peptide Sequencing Using Mirror Proteases of Ac-LysargiNase and Trypsin for Large-scale Proteomics.
Not available
S-EPMC6442358 | biostudies-literature
ProteomicsDevelopment of mirror-image monobodies targeting the oncogenic BCR::ABL1 kinase
Mirror-image proteins, composed of D-amino acids, are an attractive therapeutic modality, as they exhibit high metabolic stability and lack immunogenicity. Development of mirror-image binding proteins is achieved through chemical synthesis of D-target proteins, phage display library selection of L-b...
ORGANISM(S): Homo sapiens (Human) 
2024-10-28 | PXD056009 | Pride
Monobodies Oncogenic bcr::abl1 kinase Mirror-image-monobodies 
ProteomicsMirroring the charged termini; ETD/HCD fragmentation characteristics of LysargiNase and tryptic peptides and their benefits for peptide sequencing in proteomics
A key step in proteomics is the digestion of proteins into peptides, so far largely done by using trypsin. Tryptic digestion leads to peptides that in ESI-MS attain predominantly two charges, via protonation at the free N-terminus and at the C-terminal basic residue Arginine or Lysine. These peptide...
ORGANISM(S): Homo sapiens (Human) 
2016-12-02 | PXD004447 | Pride
Fragmentation Etd Hcd Lysarginase Orbitrap Phosphoproteomics Trypsin 
UnknownProtease-resistant peptide design-empowering nature's fragile warriors against HIV.
Not available
S-EPMC3548907 | biostudies-literature
UnknownDevelopment of mirror-image monobodies targeting the oncogenic BCR::ABL1 kinase.
Not available
S-EPMC11666773 | biostudies-literature
UnknownMirror-Image Random Nonstandard Peptides Integrated Discovery (MI-RaPID) Technology Yields Highly Stable and Selective Macrocyclic Peptide Inhibitors for Matrix Metallopeptidase 7.
Not available
S-EPMC11833282 | biostudies-literature
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