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MetabolomicsPyruvate metabolism enzyme Dlat induces mitochondria protein hyperacetylation to limit fatty acid oxidation in the HFpEF heart

Increased protein acetylation is frequently observed in the failing heart, including in hearts with heart failure with preserved ejection fraction (HFpEF). However, the role of protein acetylation in cardiac metabolic impairments during the pathogenesis of HFpEF remains insufficiently investigate...

2025-09-01 | MTBLS12919 | MetaboLights
TranscriptomicsHeLa cell mitochondrial microRNAs
MicroRNAs (miRNAs) are small non-coding RNAs that associate with Argonaute 2 protein to regulate gene expression at the post-transcriptional level in the cytoplasm. However, recent studies have reported that some miRNAs localize to and function in other cellular compartments. Mitochondria harbour th...
ORGANISM(S): Homo sapiens 
2011-10-05 | E-GEOD-24761 | biostudies-arrayexpress
ProteomicsProtein Interaction Patterns in Arabidopsis thaliana Leaf Mitochondria Change in Response to Illumination
Light is the most important cue for plant metabolism since its presence enables photosynthesis. Mitochondria respond to light conditions by adjusting flow through the citric acid cycle and the respiratory chain to support photosynthesis in the light and provide the cell with ATP in the light and in ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2021-05-17 | PXD019253 | Pride
Oxphos Plant mitochondria Protein complexes Tca-cycle Diurnal cycle Complexome profiling 
ProteomicsTargeting mitochondria-inflammation circuit by β-hydroxybutyrate mitigates heart failure with preserved ejection fraction
Rationale: Over 50% of heart failure patients have preserved, rather than reduced ejection fraction (HFpEF vs. HFrEF). Complexity of its pathophysiology and the lack of animal models hamper the development of effective therapy for HFpEF. Objective: This study was designed to investigate the metabol...
ORGANISM(S): Mus Musculus 
2021-10-22 | PXD021957 |
TranscriptomicsSmall RNA sequencing of mitochondria and whole fraction of human umbilical vein endothelial cells treated with hydrogen peroxide
Numerous miRNAs have been found in mitochondria and these mitochondrial miRNAs have been shown important roles in many physiological and pathophysiological processes. However, the dynamic changes of miRNA distribution in mitochondria in the endothelial oxidative injury are still unclear. Therefore, ...
ORGANISM(S): Homo sapiens 
2023-10-31 | E-MTAB-9851 | biostudies-arrayexpress
ProteomicsProteomics profiling of Neuronal Mitochondria
Mitochondria are the ‘power-houses’ of all cells, generating ATP to fuel numerous pathways which are vital for cellular form and function (1). Neuronal processes and synapses present a constant demand for ATP to maintain ionic gradients and neurotransmission events (2), promoting sub-populations of ...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-10-26 | PXD005537 | Pride
Neuron Proteomics Mitochondria Synapse Neurodegeneration 
GenomicsSmall RNA sequencing of mitochondria and whole fraction of human umbilical vein endothelial cells treated with hydrogen peroxide
Small RNA sequencing of mitochondria and whole fraction of human umbilical vein endothelial cells treated with hydrogen peroxide
PRJEB41690 | ENA
ProteomicsProteomics of Dictyostelium discoideum mitochondria
There is a paucity of data regarding what proteins localize to the mitochondria in the social amoeba Dictyostelium discoideum. Therefore, here, we utilized high-throughput tandem mass tag (TMT)-based protein quantitation to identify proteins in the whole-cell lysate, as well as in crude and purified...
ORGANISM(S): Dictyostelium discoideum (Slime mold) 
2022-06-06 | PXD029101 | Pride
Dictyostelium discoideum Proteomics Tmt Mitochondria purification Lcmsms 
Proteomicsbreast cancer mitochondria pulldown
pull-down of protein extracted from isolated mitochondria fraction
ORGANISM(S): Homo sapiens (Human) 
2022-02-22 | PXD030730 | Pride
Cancer Mitochondria Pull-down 
TranscriptomicsGene expression from human prefrontal cortex (BA46)
Accumulating evidence suggests that mitochondrial dysfunction underlies the pathophysiology of bipolar disorder (BD) and schizophrenia (SZ). We performed large-scale DNA microarray analysis of postmortem brains of patients with BD or SZ, and examined expression patterns of mitochondria-related genes...
ORGANISM(S): Homo sapiens 
2008-09-03 | E-GEOD-12649 | biostudies-arrayexpress
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