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TranscriptomicsThe Mitochondrial Calcium Uniporter controls skeletal muscle mass in vivo
Muscle atrophy contributes to the poor prognosis of many physiopathological conditions, but pharmacological therapies are still limited. Muscle activity leads to major swings in mitochondrial [Ca2+] which control aerobic metabolism, cell death and survival pathways. We have investigated in vivo the ...
ORGANISM(S): Mus musculus 
2015-03-05 | E-GEOD-60931 | biostudies-arrayexpress
MetabolomicsNitrate-Sialin2 Axis Couples ER-Mitochondrial Calcium Signaling with Fatty Acid Metabolism to Drive White Adipose Browning
Nutrient cues shape adipose homeostasis; however, the mechanism by which inorganic signals engage organelle networks to drive white fat browning remains unclear. Here, we identify a nitrate-Sialin2 pathway that converts dietary nitrate into a spatially confined thermogenic program. Sialin2 localizes...
2026-05-17 | MTBLS14192 | MetaboLights
ProteomicsEMRE is an Essential Component of the Mitochondrial Calcium Uniporter Complex
Not available
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2015-04-03 | MSV000079095 | MassIVE
GenomicsMitochondrial Calcium Uniporter Promotes Kidney Aging through Inducing Mitochondrial Calcium-Mediated Renal Tubular Cell Senescence
Mitochondrial Calcium Uniporter Promotes Kidney Aging through Inducing Mitochondrial Calcium-Mediated Renal Tubular Cell Senescence
PRJNA1092075 | ENA
ProteomicsMitochondrial calcium uniporter complex controls T-cell-mediated immune responses
Sustained and balanced Ca2+ increase upon T-cell receptor activation is crucial for regulation of essential T-cell functions including clonal expansion, differentiation and cytokine secretion. Thereby, mitochondria play an important role and take up Ca2+ to support elevated bioenergetic demands. The...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-10-23 | PXD048650 | Pride
Metabolism Eae Calcium Mitochondria Autoimmunity T-cell Mcu 
GenomicsMitochondrial calcium uniporter complex controls T-cell-mediated immune responses
Mitochondrial calcium uniporter complex controls T-cell-mediated immune responses
PRJNA1063709 | ENA
GenomicsExploring the in vivo role of the mitochondrial calcium uniporter in brown fat bioenergetics
Exploring the in vivo role of the mitochondrial calcium uniporter in brown fat bioenergetics
PRJNA490843 | ENA
ProteomicsMitochondrial calcium uniporter complex controls T‑cell‑mediated immune responses
Sustained and balanced calcium (Ca2+) increase upon T-cell receptor activation is a fundamental process that regulates essential T-cell functions including proliferation, clonal expansion and cytokine secretion. In this context, mitochondria play an important role and take up Ca2+ to support the ele...
ORGANISM(S): Homo sapiens (Human) 
2024-10-24 | PXD048682 | Pride
Mcu/autoimmunity/calcium/eae/metabolism/mitochondria/t-cell 
GenomicsRegulation of mitochondrial Ca2+ uniporter expression and calcium signalling by lncRNA Tug1 in cardiomyocytes
Regulation of mitochondrial Ca2+ uniporter expression and calcium signalling by lncRNA Tug1 in cardiomyocytes
PRJNA996608 | ENA
TranscriptomicsmRNA Expression Changes Induced by Myocardial MCU Inhibition
Mitochondrial calcium is an important second-messenger controlling fight-or-flight responses in the heart. The molecular identity of MCU (Mitochondrial Calcium Uniporter) was recently discovered allowing us to test this hypothesis in vivo by expressing a myocardial delimited dominant negative form ...
ORGANISM(S): Mus musculus 
2015-06-07 | E-GEOD-62049 | biostudies-arrayexpress
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