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MetabolomicsEnterococcus faecalis readily adapts membrane phospholipid composition to environmental and genetic perturbation

The bacterial lipid membrane, consisting both of fatty acid (acyl) tails and polar head groups, responds to changing conditions through alteration of either the acyl tails and/or head groups. This plasticity is critical for cell survival as it allows maintenance of both the protective nature of t...

2021-05-17 | MTBLS2080 | MetaboLights
MetabolomicsIntracellular iron overload rewires HSC metabolism by impairing mitochondrial fitness
Iron is an essential element for several cellular processes and recent evidence highlighted its role in regulating the function of hematopoietic stem cells (HSCs). When in excess it reduces quiescence and self-renewal, however, whether and how iron influences HSC metabolism is still unknown. Here, w...
2024-12-04 | MTBLS11778 | MetaboLights
MetabolomicsPhospholipid acyl chain diversity controls the tissue-specific assembly of mitochondrial cardiolipins

Cardiolipin (CL) is a phospholipid specific for mitochondrial membranes and crucial for many core tasks of this organelle. Its side chain configurations are tissue-specific, functionally important and generated via post-biosynthetic remodeling. However, this process lacks the necessary specificit...

2020-05-22 | MTBLS1446 | MetaboLights
UnknownHBimmCue: A Versatile Fluorescent Probe for Multi-Scale Imaging of Lipid Polarity and Membrane Order in Inner Mitochondrial Membrane.
Not available
S-EPMC11967834 | biostudies-literature
ProteomicsImpaired protein import drives mitochondrial dysfunction upon mutation of TIMM50 in mitochondrial disease
TIMM50 is a core subunit of the TIM23 complex, the mitochondrial inner membrane translocase responsible for the import of presequence-containing precursors into the matrix or inner membrane. Here we describe a mitochondrial disease patient that is homozygous for a novel variant in TIMM50 and establi...
ORGANISM(S): Homo sapiens (Human) 
2024-07-03 | PXD047774 | Pride
Mitochondrial protein import Tim23 complex Mitochondria Timm50 Mitochondrial disease 
ProteomicsLabel free quantitative proteomics reveals survival mechanisms developed by Hypertrophic chondrocytes under ER stress
Emerging evidence implicates ER stress caused by unfolded mutant proteins in chondrocytes as the underlying pathology of chondrodysplasias. ER stress is triggered in hypertrophic chondrocytes (HCs) in a mouse model (13del) of metaphyseal chondrodysplasia type Schmid (MCDS) caused by misfolded mutan...
ORGANISM(S): Mus musculus (Mouse) 
2015-11-25 | PXD002125 | Pride
Metaphyseal chondrodysplasia type schmid Mitochondrial membrane polarity Glycolysis Calcium signaling 
ProteomicsLegionella effector LpPIP recruits protein phosphatase 1 to the mitochondria to induce dephosphorylation of outer membrane proteins
Legionella pneumophila utilises a type IVB secretion system (T4SS) to translocate over 300 effectors into host cells, hijacking cellular processes, including those within the mitochondrion. Currently, no Legionella effectors have been identified at the mitochondrial outer membrane, a critical interf...
ORGANISM(S): Homo sapiens (Human) 
2025-06-03 | PXD057005 | Pride
Mitochondrial outer membrane Protein phosphatase 1 Legionella pneumophila Effector proteins Mitochondria Tail-anchored protein Rvxf motif Type ivb secretion system 
ProteomicsMitochondria regulate intracellular coenzyme Q transport and ferroptotic resistance via STARD7
Coenzyme Q (or ubiquinone) is a redox-active lipid, which serves as universal electron carrier in the mitochondrial respiratory chain and antioxidant in the plasma membrane limiting lipid peroxidation and ferroptosis. Mechanisms allowing cellular coenzyme Q distribution after synthesis within mitoch...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-11-12 | PXD033064 | Pride
Mitochondria Stard7 Coq 
ProteomicsMulti-facetted proteomics of mitochondrial TMBIM5 deficient cell lines: Regulation of mitochondrial proteostasis by the proton gradient
Mitochondria adapt to different energetic demands reshaping their proteome. Mitochondrial proteases are emerging as key regulators of these adaptive processes. Here, we use a multi-proteomic approach to demonstrate regulation of the m-AAA protease AFG3L2 by the mitochondrial proton gradient, couplin...
ORGANISM(S): Homo sapiens (Human) 
2022-07-26 | PXD030095 | Pride
Cyclohexamide Hek Mitochondria Ghitm Hela Silac Afg3l2 Tmbim5 
TranscriptomicsSMALL EXTRACELLULAR VESICLE REGULATION OF MITOCHONDRIAL DYNAMICS REPROGRAMS A HYPOXIC TUMOR MICROENVIRONMENT
The crosstalk between tumor cells and the adjacent normal epithelium contributes to cancer progression, but its regulators have remained elusive. Here, we show that breast cancer cells maintained in hypoxia release small extracellular vesicles (sEV) that activate mitochondrial dynamics, stimulate mi...
ORGANISM(S): Homo sapiens 
2020-11-12 | GSE154340 | GEO
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