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ProteomicsComplexome profiling of HEK293 WT and TMBIM5 mitochondria
Mitochondria adapt to different energetic demands reshaping their proteome. Mitochondrial proteases are emerging as key regulators of these adaptive processes. Here, we use a multi-proteomic approach to demonstrate regulation of the m-AAA protease AFG3L2 by the mitochondrial proton gradient, couplin...
ORGANISM(S): Homo sapiens (Human) 
2022-07-26 | PXD033084 | Pride
Complexome profiling Tmbim5 Hek293 
UnknownInteraction of the mitochondrial calcium/proton exchanger TMBIM5 with MICU1.
Not available
S-EPMC12449474 | biostudies-literature
ProteomicsMulti-facetted proteomics of mitochondrial TMBIM5 deficient cell lines: Regulation of mitochondrial proteostasis by the proton gradient
Mitochondria adapt to different energetic demands reshaping their proteome. Mitochondrial proteases are emerging as key regulators of these adaptive processes. Here, we use a multi-proteomic approach to demonstrate regulation of the m-AAA protease AFG3L2 by the mitochondrial proton gradient, couplin...
ORGANISM(S): Homo sapiens (Human) 
2022-07-26 | PXD030095 | Pride
Cyclohexamide Hek Mitochondria Ghitm Hela Silac Afg3l2 Tmbim5 
UnknownTMBIM5 loss of function alters mitochondrial matrix ion homeostasis and causes a skeletal myopathy.
Not available
S-EPMC9206080 | biostudies-literature
UnknownTransmembrane BAX Inhibitor-1 Motif Containing Protein 5 (TMBIM5) Sustains Mitochondrial Structure, Shape, and Function by Impacting the Mitochondrial Protein Synthesis Machinery.
Not available
S-EPMC7598220 | biostudies-literature
UnknownTMBIM5 is the Ca<sup>2+</sup> /H<sup>+</sup> antiporter of mammalian mitochondria.
Not available
S-EPMC9724676 | biostudies-literature
UnknownTMBIM5 is the Ca2+/H+ antiporter of mammalian mitochondria
Not available
S-SCDT-10_15252-EMBR_202254978 | biostudies-other
ProteomicsProteomic analysis of differentially expressed proteins in TMBIM5-overexpressing cells under PA stimulation compared to control PA-treated AML12 cells
This project aims to identify differentially expressed proteins between the Ctrl+PA group and the OE-TMBIM5+PA group using proteomic analysis. Cells were lysed with RIPA buffer containing protease inhibitors, followed by ultrasonication and centrifugation to collect the supernatant. Proteins were di...
ORGANISM(S): Mus Musculus 
PXD077230 |
UnknownRegulation of mitochondrial proteostasis by the proton gradient.
Not available
S-EPMC9379554 | biostudies-literature
UnknownRegulation of mitochondrial proteostasis by the proton gradient
Not available
S-SCDT-EMBOJ-2021-110476 | biostudies-other
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