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TranscriptomicsThe human mitochondrial transcriptome
The human mitochondrial genome comprises a distinct genetic system transcribed as precursor polycistronic transcripts that are subsequently cleaved to generate individual mRNAs, tRNAs and rRNAs. Here we provide a comprehensive analysis of the human mitochondrial transcriptome across multiple cell li...
ORGANISM(S): Homo sapiens 
2011-07-20 | E-GEOD-30772 | biostudies-arrayexpress
TranscriptomicsSmall and large RNA sequencing of mouse livers receiving small hairpin RNAs
Adeno-associated viral (AAV) small hairpin (shRNA) expression vectors are a promising therapeutic but can induce severe liver toxicity when delivered at high albeit undefined doses. Using various AAV-shRNA vectors under the high-expressing U6 and low-expressing H1 promoters, we found that dose-limi...
ORGANISM(S): Mus musculus 
2016-03-09 | E-GEOD-69186 | biostudies-arrayexpress
ProteomicsMechanism of mitoribosomal small subunit biogenesis and preinitiation
Mitoribosomes are essential for synthesis and maintenance of bioenergetic proteins. Here, we use cryoelectron microscopy (cryo-EM) to determine a series of the small mitoribosomal subunit (SSU) intermediates in complex with auxiliary factors, revealing a sequential assembly mechanism. The methyltran...
ORGANISM(S): Homo sapiens (Human) 
2022-07-11 | PXD031678 | Pride
Silac Sucrose gradient Translation initiation Mitoribosome 
TranscriptomicsmRNA Sequencing of skeletal muscle genes in wildtype and BCATm (BCAT2) KO mice
Consumption of a protein containing meal by a fasted animal promotes protein accretion in skeletal muscle, in part through leucine stimulation of protein synthesis and indirectly through repression of protein degradation mediated by its metabolite, α-ketoisocaproate. Mice lacking the mitochondrial ...
ORGANISM(S): Mus musculus 
2015-12-11 | E-GEOD-68915 | biostudies-arrayexpress
ProteomicsStress signaling and cellular proliferation reverse the effects of mitochondrial mistranslation
The fidelity of translation is crucial in prokaryotes and for the nuclear-encoded proteins of eukaryotes, however little is known about the role of mistranslation in mitochondria and its effects on metabolism. We generated yeast and mouse models with error-prone and hyperaccurate mitochondrial trans...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-08 | PXD015456 | Pride
Oxidative phosphorylation Mitochondrial ribosome  mrps12 Stress response abbreviations used: mitoribosome Mitochondrial ribosomal protein of the small subunit 12  oxphos Mitochondria Metabolism Protein synthesis 
TranscriptomicsParkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration
Parkinson's disease (PD) is an adult-onset movement disorder of largely unknown etiology. We have previously shown that loss-of-function mutations of the mitochondrial protein kinase PINK1 (PTEN induced putative kinase 1) cause the recessive PARK6 variant of PD. Now we generated a PINK1 deficient mo...
ORGANISM(S): Mus musculus 
2014-11-04 | E-GEOD-60413 | biostudies-arrayexpress
TranscriptomicsGene expression analysis in 13 patients with mitochondrial ATP synthase deficiency (MitoArray)
Defects of mitochondrial functions lead in humans to vast array of usually multisystemic pathologies and several hundreds of diseases resulting from various defects of mitochondria biogenesis and maintenance, defects of respiratory chain complexes (OXPHOS) or defects of individual mitochondrial prot...
ORGANISM(S): Homo sapiens 
2010-06-05 | E-GEOD-8648 | biostudies-arrayexpress
UnknownThe fragmented mitochondrial ribosomal RNAs of Plasmodium falciparum.
Not available
S-EPMC3382252 | biostudies-literature
TranscriptomicsPervasive and dynamic protein binding sites of the mRNA transcriptome in Saccharomyces cerevisiae
Protein-RNA interactions are integral components of nearly every aspect of biology including regulation of gene expression, assembly of cellular architectures, and pathogenesis of human diseases. However, studies in the past few decades have only uncovered a small fraction of the vast landscape of t...
ORGANISM(S): Saccharomyces cerevisiae 
2013-01-29 | E-GEOD-43747 | biostudies-arrayexpress
TranscriptomicsImproved transcription and translation with L-leucine stimulation of mTORC1
Roberts syndrome (RBS) is a human developmental disorder caused by mutations in the cohesin acetyltransferase ESCO2. We previously reported that mTORC1 was inhibited and overall translation was reduced in RBS cells. Treatment of RBS cells with L-leucine partially rescued mTOR function and protein sy...
ORGANISM(S): Homo sapiens 
2016-01-15 | E-GEOD-64962 | biostudies-arrayexpress
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