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We measure changes in the proteome after 48 hours of activity deprivation with tetrodotoxin (TTX) and the NMDA receptor antagonist (2R)-amino-5-phosphonovaleric acid (APV). We used wild type and FMRP mutant primary cortical neurons treated with vehicle or treated with TTX-APV.
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD021473 | Pride
We analyzed the proteomic changes that occur in a Fbxl4 knock-out 1-year mouse. We analyzed Liver tissue using a 6-plex TMT approach (3 KO and 3 controls). Since we observed a global decrease in mitochondrial proteins, we also explored mitoproteome changes in different tissues (liver, kidney and hea...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-06-10 | PXD018639 | Pride
Mitochondrial gene expression relies on mitoribosomes to translate mitochondrial mRNAs. The biogenesis of mitoribosomes is an intricate process involving multiple assembly factors. Among these factors, GTP-binding proteins (GTPBPs) play crucial roles. In bacterial systems, numerous GTPBPs are requir...
ORGANISM(S): Homo sapiens (Human) 
2024-04-11 | PXD045264 | Pride
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