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TranscriptomicsGenomic expression patterns of mitral valve tissues from dogs with degenerative mitral valve disease
Evaluation of global expression patterns provides a molecular portrait of mitral valve disease, yields insight into the pathophysiologic aspects of DMVD, and identifies intriguing genes and pathways for further study. (Am J Vet Res 2006;67:1307–1318) Keywords: control vs diseased 4 controls( beagle ...
ORGANISM(S): Canis lupus familiaris 
2008-05-15 | E-GEOD-11460 | biostudies-arrayexpress
TranscriptomicsSingle cell sequencing of developing heart valves identifies novel cell populations and uncovers interstitial cell heterogeneity
This study has two main goals. The first is to define a gene expression atlas of heart valve cells and identify cell heterogeneity within postnatal heart valve development. The second is to identify interstitial cell populations involved in ECM remodeling during postnatal heart valve development. Ov...
ORGANISM(S): Mus musculus 
2018-07-13 | E-HCAD-18 | biostudies-arrayexpress
ProteomicsNormal human mitral valve proteome: a preliminary investigation by gel-based and gel-free proteomic approaches
The mitral valve is a highly complex structure which regulates blood flow from the left atrium to the left ventricle (LV) avoiding a significant forward gradient during diastole or regurgitation during systole. The integrity of the mitral valve is also essential for the maintenance of normal LV size...
ORGANISM(S): Homo sapiens (Human) 
2016-08-18 | PXD004397 | Pride
Human normal mitral valve Lc/mse Valvular interstitial cells 
ProteomicsMitral Valve Tissue Shotgun Proteomics
In this study, we carried out a large-scale proteome profiling of human mitral valve tissues resected from patients with mitral valve prolapse.
ORGANISM(S): Homo sapiens (Human) 
2015-05-07 | PXD000774 | Pride
Mitral valve Tissue Lc-ms/ms 
TranscriptomicsExpression analysis of human aortic valve interstitial cells (hAVICs), mitral valve interstitial cells(hMVICs) and dermal firbroblasts (hDFs)
Investigation of whole genome gene expression level changes in hAVICs and hMVICs, compared to human dermal fibroblasts. A three chip assay using total RNA obtained from primary cultured normal valve interstital cells and human dermal fibroblasts was performed. Each chip measures the expression level...
ORGANISM(S): Homo sapiens 
2013-06-30 | E-GEOD-40801 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse E12.5 AV cushion and E17.5 AV valve from wild-type FVB/N mice and in vitro cultured MC3T3 cells
E12.5 AV cushion and E17.5 AV valve from wild-type FVB/N mice and in vitro cultured MC3T3 cells; In the study we demonstrated shared gene expression in embryonic heart valve development and Osteoblast progenitor cells. The atrioventricular (AV) valves of the heart develop from undifferentiated mesen...
ORGANISM(S): Mus musculus 
2008-10-21 | E-GEOD-11040 | biostudies-arrayexpress
TranscriptomicsValvular heart disease and atrial fibrillation regulate microRNA expression profiles in left and right atria differently
Background: Chronic atrial fibrillation (AF) is a complication associated with the dilated atria of patients with valvular heart disease and contributes to worsened pathology. Methods and Results: Using microarray technology, we examined microRNA (miR) expression profiles in right and left atrial ap...
ORGANISM(S): Homo sapiens 
2011-12-21 | E-GEOD-28954 | biostudies-arrayexpress
GenomicsmTOR signal in mitral valve diseases
mTOR signal in mitral valve diseases
PRJNA1247445 | ENA
ProteomicsSerum proteome profiling across different stages of myxomatous mitral valve disease in domestic dogs
Development and progression of myxomatous mitral valve disease (MMVD) in domestic dogs is unpredictable and pathobiology still unclear. The American College of Veterinary Internal Medicine (ACVIM) perceived that mayor improvement in management of diseased dogs would be timely diagnosis, especially d...
ORGANISM(S): Bos taurus (Bovine) 
2023-05-10 | PXD038475 | Pride
Myxomatous mitral valve disease Degenerative mitral valve disease Tmt proteomics Dogs Serum 
TranscriptomicsAffymetrix GeneChip™ Canine Gene 1.1ST Array of canine heart valves in all stages of Myxomatous mitral valve disease (Normal-4)
Whole mitral valves from each Whitney grade of disease; normal (n=6), grade 1 (n=5), grade 2 (n=6), grade 3 (n=6) and grade 4 (n=5). mRNA was extracted using the qiagen RNeasy minikit and assessed by the agilent 2200 bioanalsyser. all samples passed quality control and transcriptomic analysis was pe...
ORGANISM(S): Canis lupus familiaris 
2019-12-26 | E-MTAB-8618 | biostudies-arrayexpress
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