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TranscriptomicsOver-expression of MBF1c enhances stress tolerance
Multiprotein bridging factor 1c MBF1c (At3g24500) is a stress-response transcription co-activator. To test the function of MBF1c, we over-expressed it in transgenic Arabidopsis plants using the 35S-CaMV promoter. T4 seeds form 3 independent lines were tested for their tolerance to biotic and abiotic...
ORGANISM(S): Arabidopsis thaliana 
2008-06-13 | E-GEOD-5539 | biostudies-arrayexpress
ProteomicsDisrupting CISD2 function in cancer cells primarily alters mitochondrial labile iron status and triggers reactive oxygen species accumulation
The multiple functions of CISD2 in cells could result from its role in calcium signaling, iron and/or iron-sulfur homeostasis, and/or ROS signaling/homeostasis. The relationship(s) and interdependency between these different signaling and homeostasis processes are however unclear at present, since m...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-05-15 | MSV000087436 | MassIVE
TranscriptomicsParallel expression evolution of oxidative stress-related genes in fiber of wild/domesticated & diploid/polyploid cotton
Reactive oxygen species (ROS) play a prominent role in signal transduction and cellular homeostasis in plants. However, imbalances between generation and elimination of ROS can give rise to oxidative stress in growing cells. Because ROS are important to cell growth, ROS modulation could be responsiv...
ORGANISM(S): Gossypium tomentosum 
2009-07-24 | E-GEOD-17084 | biostudies-arrayexpress
ProteomicsROS are evolutionary conserved cell-to-cell stress signals
Cell-to-cell communication is fundamental to multicellular organisms and unicellular organisms living in a microbiome. It is thought to have evolved as a stress- or quorum-sensing mechanism in unicellular organisms. A unique cell-to-cell communication mechanism that uses reactive oxygen species (ROS...
ORGANISM(S): Chlamydomonas reinhardtii 
2024-05-24 | PXD042594 | Pride
Dia-pasef Reactive oxygen species (ros) Cell-to-cell communication 
ProteomicsA peptide-derived strategy for specifically targeting the mitochondrial-ER network of cancer cells: a new paradigm in fighting cancer
An effective anti-cancer therapy should exclusively target cancer cells and trigger in them a broad spectrum of cell death pathways that will prevent avoidance. Here, we present a novel paradigm in cancer therapy that specifically targets the mitochondria and ER of cancer cells. We developed a pepti...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD030509 | Pride
Cancer Cisd2 Mitochondria Peptides Er Naf-1 Cell death 
TranscriptomicsABA is required for plant acclimation to a combination of salt and heat stress
We examined changes in steady-state transcript level in leaves of Arabidopsis plants subjected to salinity, heat stress and their combination by a transcriptome analysis of leaves. mRNA profiles of Arabidopsis plants subjected to salinity, heat stress and their combination were generated by RNA-Seq ...
ORGANISM(S): Arabidopsis thaliana 
2016-10-24 | E-GEOD-72806 | biostudies-arrayexpress
ProteomicsPropagation of a rapid cell-to-cell H2O2 signal over long distances in a monolayer of cardiomyocyte cells
Cell-to-cell communication plays a cardinal role in the biology of multicellular organisms. H2O2 is an important cell-to-cell signaling molecule involved in the response of mammalian cells to wounding and other stimuli. We previously identified a signaling pathway that transmits wound-induced H2O2 c...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-05-24 | PXD047131 | Pride
Hydrogen peroxide Cell-to-cell Superoxide Signal transduction Proteomics Gap junction 
Transcriptomicssystemic signal
Effects of local stress treatments (heat, high light or wounding) on transcripts in systemic tissues in Arabidopsis
ORGANISM(S): Arabidopsis thaliana 
2013-09-08 | E-MEXP-3754 | biostudies-arrayexpress
UnknownIL-1α is a DNA damage sensor linking genotoxic stress signaling to sterile inflammation and innate immunity.
Not available
S-EPMC4593953 | biostudies-literature
ProteomicsFeS protein levels in Arabidopsis plants expressing a mutated NEET protein
Iron-sulfur (Fe-S) clusters play an essential role in plants as protein co-factors mediating diverse electron transfer reactions. Because they can react with oxygen to form reactive oxygen species (ROS) and cause cellular damage, the biogenesis of Fe-S clusters is highly regulated. A newly discovere...
ORGANISM(S): Arabidopsis Thaliana 
2021-01-24 | PXD015447 | panorama
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