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TranscriptomicsThe histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged leukemia
MLL-fusions are potent oncogenes that initiate aggressive forms of acute leukemia. As aberrant transcriptional regulators, MLL-fusion proteins alter gene expression in hematopoietic cells through interactions with the histone H3 lysine 79 (H3K79) methyltransferase DOT1L. Notably, interference with M...
ORGANISM(S): Mus musculus 
2013-02-19 | E-GEOD-43725 | biostudies-arrayexpress
ProteomicsQuantitative cellular proteome analysis of Fetal- and Adult-Derived MLL-Rearranged Leukemia
Infant and adult MLL-rearranged (MLLr) leukemia represents a disease with few treatment options and a dismal prognosis. Here, we present an in-depth proteomic characterization of in utero-initiated and adult-onset MLLr leukemia in a mouse model of MLL-ENL-mediated leukemogenesis. We characterize ear...
ORGANISM(S): Mus musculus (Mouse) 
2024-04-02 | PXD042249 | Pride
Adult hematopoietic progenitor Tmtpro Mll-rearranged leukemia Fetal hematopoietic progenitor 
ProteomicsProteome alterations in MLL-rearranged leukemia cells following WIN Site inhibition
WIN Site inhibitors bind the WIN Site of WDR5 resulting in decreased transcription of WDR5 target genes, many of which encode components of the protein synthesis machinery. In this study, we determined proteome alterations in an MLL-rearranged leukemia cell line treated for either 24 or 72 hours wit...
ORGANISM(S): Homo sapiens (Human) 
2023-07-04 | PXD035129 | Pride
Proteomics Acute myeloid leukemia Ribosome Wdr5 Label-free quantification Chromatin Translation 
TranscriptomicsTranscription profling of infants (<1 year of age) diagnosed with Acute Lymphoblastic Leukemia (ALL) characterised by genomic translocation.
Acute Lymphoblastic Leukemia (ALL) in infants (<1 year) is characterized by a poor prognosis and a high incidence of MLL translocations. Several studies demonstrated the unique gene expression profile associated with MLL-rearranged ALL, but generally small cohorts were analyzed as uniform patient gr...
ORGANISM(S): Homo sapiens 
2009-12-15 | E-GEOD-19475 | biostudies-arrayexpress
TranscriptomicsDevelopment of MLL-rearranged leukemia is dependent on a transcriptional program orchestradt by C/EBPα
Translocations involving the MLL genes are frequently found in Acute Myeloid Leukemia (AML) and are associated with poor prognosis. The MLL fusion proteins act as aberrant transcription factor activating a transcriptional program that transforms the cells, potentially through collaboration with othe...
ORGANISM(S): Mus musculus 
2013-12-10 | E-GEOD-46534 | biostudies-arrayexpress
GenomicsMBNL1 regulates essential alternative RNA splicing patterns in MLL-rearranged leukemia
MBNL1 regulates essential alternative RNA splicing patterns in MLL-rearranged leukemia
PRJNA508759 | ENA
TranscriptomicsExpression changes after loss of Dot1l in murine MLL-AF9 leukemia cells
MLL-fusions may induce leukemogenic gene expression programs by recruiting the histone H3K79 methyltransferase to MLL-target promoters. We evaluated gene expression changes after cre-mediated loss of Dot1l in leukemia cells obtained from mice injected with MLL-9 transformed lineage negative bone mar...
ORGANISM(S): Mus musculus 
2011-09-12 | E-GEOD-25911 | biostudies-arrayexpress
UnknownIdentification of MLL-fusion/MYC⊣miR-26⊣TET1 signaling circuit in MLL-rearranged leukemia.
Not available
S-EPMC4809417 | biostudies-literature
UnknownSETD2-mediated crosstalk between H3K36me3 and H3K79me2 in MLL-rearranged leukemia.
Not available
S-EPMC6277029 | biostudies-literature
GenomicsTet1 plays an essential oncogenic role in MLL-rearranged leukemia
TET1, the founding member of the TET family of enzymes (TET1/2/3) that convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), was first identified as a partner gene in MLL-rearranged leukemia, but its definitive pathological role in leukemia is unclear. The down-regulation of all three TE...
ORGANISM(S): Mus musculus 
2015-12-14 | E-GEOD-42990 | biostudies-arrayexpress
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