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ProteomicsChromatin-associated RNA degradation contributes to silencing of Polycomb target genes
Polycomb Repressive Complexes 1 and 2 (PRC1 and PRC2) are histone-modifying and -binding complexes that mediate the formation of facultative heterochromatin and are required for silencing of developmental genes and maintenance of cell fate. Multiple pathways of RNA decay work together to establish a...
ORGANISM(S): Homo sapiens (Human) 
2022-01-20 | PXD029403 | Pride
Polycomb repressive complex rixosome rna degradation wdr18 nol9 
TranscriptomicsArgonaute Surveillance and Dicer-Independent priRNAs TriggerRNAi and Heterochromatin Formation
The assembly of fission yeast pericentromeric heterochromatin and generation of small interfering RNAs (siRNAs) from noncoding centromeric transcripts are mutually dependent processes. How this interdependent positive feedback loop is first triggered is a fundamental unanswered question. Here we sho...
ORGANISM(S): Schizosaccharomyces pombe 
2010-02-23 | E-GEOD-19734 | biostudies-arrayexpress
UnknownDNA sequence-dependent epigenetic inheritance of gene silencing and histone H3K9 methylation.
Not available
S-EPMC5718040 | biostudies-literature
TranscriptomicsDeterminants of heterochromatic siRNA biogenesis and function
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Schizosaccharomyces pombe 
2013-12-26 | E-GEOD-52535 | biostudies-arrayexpress
UnknownEpigenetic inheritance mediated by coupling of RNAi and histone H3K9 methylation.
Not available
S-EPMC6312107 | biostudies-literature
UnknownDistinct Functions of Argonaute Slicer in siRNA Maturation and Heterochromatin Formation.
Not available
S-EPMC5576859 | biostudies-literature
ProteomicsA Composite DNA Element that Functions as a Maintainer Required for Epigenetic Inheritance of Heterochromatin
Epigenetic inheritance of heterochromatin requires DNA sequence-independent propagation mechanisms, coupling to RNAi, or input from DNA sequence, but how DNA contributes to inheritance is not understood. Here, we identify a DNA element (termed “maintainer”) that is sufficient for epigenetic inherita...
ORGANISM(S): Schizosaccharomyces pombe 927 
2022-10-14 | PXD027214 | Pride
Maintainer H3k9me Methylation pombe Heterochromatin 
UnknownEpigenetics. Epigenetic inheritance uncoupled from sequence-specific recruitment.
Not available
S-EPMC4385470 | biostudies-literature
ProteomicsChromatin-associated RNA degradation contributes to silencing of Polycomb target genes
Polycomb Repressive Complexes 1 and 2 (PRC1 and PRC2) are histone-modifying and -binding complexes that mediate the formation of facultative heterochromatin and are required for silencing of developmental genes and maintenance of cell fate. Multiple pathways of RNA decay work together to establish a...
ORGANISM(S): Homo sapiens (Human) 
2022-01-19 | PXD027966 | Pride
Prc2 Polycomb Prc1 Rix1 Rna degradation Rixosome 
UnknownDeterminants of heterochromatic siRNA biogenesis and function.
Not available
S-EPMC4357591 | biostudies-literature
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