Sort   by:  
 Page size 
ProteomicsIndolin-2-one nitroimidazole antibiotics exhibit an unexpected dual mode of action
Nitroimidazoles such as metronidazole are used as anti-infective drugs against anaerobic bacteria. Upon in vivo reduction of the nitro group, reactive radicals damage DNA and proteins in the absence of oxygen. Unexpectedly, a recent study of nitroimidazoles linked to an indolin-2-one substituent rev...
ORGANISM(S): Staphylococcus aureus 
2022-11-09 | PXD033128 | Pride
Antibiotics Target-id Abpp 
Proteomics5-Nitroimidazole ethers boost anti-Helicobacter pylori activity via a dual mode of action and effectively eradicate infections in vivo
Metronidazole (Metro) represents the front line-drug against Helicobacter pylori infections, but despite its crucial role as an antibiotic, little is known about its exact mode of action (MoA). To unravel cellular protein targets, we here performed activity-based protein profiling (ABPP) with tailor...
ORGANISM(S): Helicobacter pylori 26695 
2026-04-13 | PXD051773 | Pride
Abpp Full proteome Helicobacter pylori Mode of action Nitroimidazoles Secretome Lc-ms/ms 
ProteomicsMetaomic study on the ecophysiological cascade underlaying seasonal N2O emissions
Nina Roothans et al.(2024) combined long-term, metagenomically resolved metaproteomics and ex situ kinetic characterizations to elucidate the ecophysiology of an N2O-emitting wastewater treatment plant community. The integration of these data enabled the identification of a cascade of environmental ...
ORGANISM(S): Microthrix Candidatus Accumulibacter phosphatis Nitrosomonas sp. Nitrospira sp. 
2025-02-21 | PXD051095 | Pride
Wastewater treatment plants Microbes Shotgun proteomics Metaproteomics 
ProteomicsN-terminomics profiling of host proteins targeted by excretory-secretory proteases of the nematode Angiostrongylus vasorum identifies points of interaction with canine coagulation and complement cascade
The cardiopulmonary nematode Angiostrongylus vasorum can cause severe disease in dogs, including coagulopathies manifesting with bleeding. We analysed A. vasorum excretory/secretory protein (ESP)-treated dog plasma and serum by N-terminome analysis using Terminal Amine Isotopic Labelling of Substrat...
ORGANISM(S): Angiostrongylus vasorum Canis familiaris (Dog) (Canis lupus familiaris) 
2025-05-07 | PXD056659 | Pride
Dog Serum French heartworm Plasma Tails 
TranscriptomicsTranscriptomic responses of zebrafish embryos to sublethal exposure to androstenedione: A 96-Hour RNA-seq Study
Endocrine active substances pose risks to both human health and the environment, potentially impacting crucial endocrine-regulated functions like organism development and reproductive capability. However, current testing methods for chemical risk assessment are time-consuming, expensive, and involve...
ORGANISM(S): Danio rerio 
2024-08-31 | E-MTAB-14033 | biostudies-arrayexpress
TranscriptomicsKetogulonigenium vulgare cells: co-culture mode vs. mono-culture mode
Transcriptional profiling of K. vulgare cells co-cultured with Bacillus megaterium compared to K. vulgare mono-cultured cells. Differentially expressed genes in co-cultured and mono-cultured K. vulgare cells were analyzed. The aim was to investigate the mechanisms of B. megaterium stimulating K. vul...
ORGANISM(S): Bacillus megaterium 
2012-04-25 | E-GEOD-37594 | biostudies-arrayexpress
ProteomicsLC-MS/MS analysis of immunoprecipitated NAA15-V5 variants
The human N-terminal acetyltransferase E (NatE) including its associated NatA co-translationally acetylates the N-terminus of about 40-60% of the proteome to mediate diverse biological processes including protein half-life, localization and protein interaction. In eukaryotes, the NatE complex contai...
ORGANISM(S): Homo sapiens (Human) 
2020-03-13 | PXD017031 | Pride
Lc-ms/ms N-terminal acetylation Nate Naa15 Naa10 Hypk Naa50 
GenomicsTelomere Binding Protein TRB1 Preferentially Associates with Promoters of Translation Machinery genes
Background: Recently we characterised TRB1, a protein from a single-myb-histone family, as a structural and functional component of telomeres in Arabidopsis thaliana. TRB proteins, besides their ability to bind specifically telomeric DNA using their N-terminally positioned myb-like domain of the sam...
ORGANISM(S): Arabidopsis thaliana 
2015-12-21 | E-GEOD-69431 | biostudies-arrayexpress
TranscriptomicsMicroRNA-182-5p targets a network of genes involved in DNA repair
MicroRNAs are non-coding regulators of gene expression, which act by repressing protein translation and/or degrading mRNA. Many have been shown to drive tumorigenesis in cancer, but functional studies to understand their mode of action are typically limited to single target genes. In this study we u...
ORGANISM(S): Homo sapiens 
2013-01-29 | E-GEOD-38593 | biostudies-arrayexpress
MetabolomicsBridging Targeted (Zeno MRM-HR) and Untargeted (SWATH) LC–HRMS in a Single Run for Sensitive Exposomics

Traditionally, chemical exposure has been assessed by low-resolution mass spectrometry via targeted approaches due to the typically extremely low concentration of such compounds in biological samples. Nevertheless, untargeted approaches are now becoming a promising tool for a broader investigatio...

2025-08-28 | MTBLS10565 | MetaboLights
Sort   by:  
 Page size