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ProteomicsComprehensive Proteomic Exploratory of Gingival Crevicular Fluid Identifies Complement and Neutrophil-Associated Alterations in Gingivitis and Periodontitis Progression
Aim: To provide an exploratory proteomic characterization of periodontal disease-related immune pathways by analyzing gingival crevicular fluid, revealing subtle proteomic changes accompanying disease progression. Materials and methods: Gingival crevicular fluid samples were collected from normal (c...
ORGANISM(S): Homo sapiens (Human) 
2026-01-05 | PXD065250 | Pride
Gingivitis  periodontitis  proteomics  complement  neutrophils 
ProteomicsComparative Proteomics of Tissue and Gingival Crevicular Fluid in Periodontitis
Periodontitis is an inflammatory condition affecting periodontal tissues, such as the gingiva and alveolar bone, surrounding the teeth. However, previous research has focused on analyzing a single sample type, such as tissue, blood, or gingival crevicular fluid (GCF), which may limit the comprehensi...
ORGANISM(S): Homo sapiens (Human) 
2026-04-06 | PXD054953 | Pride
Proteomics Periodontitis Neutrophil Gcf Systemic inflammation 
ProteomicsDifferential Protein Expression and Metabolite Profiling in Glaucoma: Insights from a Multi-Omics Analysis
Glaucoma is a group of diseases characterized by progressive optic nerve damage leading to irreversible visual field loss, often associated with elevated intraocular pressure (IOP). However, the specific underlying factors or molecular mechanisms distinguishing various glaucoma subtypes are still no...
ORGANISM(S): Homo sapiens (Human) 
2024-04-11 | PXD046219 | Pride
Proteomics Multi-omics Metabolomics Pseudoexfoliation Primary open-angle glaucoma Extracellular matrix 
ProteomicsOptimizing MS-based multi-omics: comparative analysis of protein, metabolite, and lipid extraction techniques
Multi-omics integrates diverse types of biological information from genomic, proteomic, and metabolomics experiments to achieve a comprehensive understanding of complex cellular mechanisms. However, this approach is also challenging due to technical issues such as limited sample quantities, complex...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD047010 | Pride
Lc-ms Fasp Matyash method S-trap Multi-omics Folch method 
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