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ProteomicsFirst-in-class DUB Molecular Glues and Inhibitors of Inflammation
Deubiquitylases (DUBs) play a pivotal role in cell signalling and are often regulated by homo- or hetero-interactions within protein complexes. The BRCC36 isopeptidase complex (BRISC) regulates inflammatory signalling by selectively cleaving K63-linked polyubiquitin chains on Type I interferon recep...
ORGANISM(S): Homo sapiens (Human) 
2025-02-06 | PXD044584 | Pride
Inhibitor Molecular glues Hydrogen deuterium exchange Hdx Deubiquitylase 
ProteomicsContinuous evolution of compact protein degradation tags regulated by selective cereblon molecular glues
Small molecule-triggered protein degradation tags (degrons) are powerful tools for biology, biotechnology, and therapeutics development. Commonly used degrons, however, are large protein domains (typically >100 amino acids) that cannot be easily or cleanly installed in endogenous protein-coding gene...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-09 | PXD047593 | Pride
Degron Protein degradation Cereblon Phase-assisted evolution Molecular glues 
UnknownDiscovery of fully synthetic FKBP12-mTOR molecular glues.
Not available
S-EPMC11796051 | biostudies-literature
UnknownModulation of Protein-Protein Interactions with Molecular Glues in a Synthetic Condensate Platform.
Not available
S-EPMC11826995 | biostudies-literature
UnknownTemplate-assisted covalent modification underlies activity of covalent molecular glues.
Not available
S-EPMC11582070 | biostudies-literature
UnknownMolecular Glues Stabilize Water-Mediated Hydrogen Bonds in Ternary Complexes.
Not available
S-EPMC12833552 | biostudies-literature
UnknownUnveiling the hidden interactome of CRBN molecular glues.
Not available
S-EPMC12289921 | biostudies-literature
ProteomicsCovalent 14-3-3 Molecular Glues and Heterobifunctional Molecules Against Nuclear Transcription Factors and Regulators
14-3-3 proteins have the unique ability to bind and sequester a multitude of diverse phosphorylated signaling proteins and transcription factors. Many previous studies have shown that 14-3-3 interactions with specific phosphorylated substrate proteins can be enhanced through small-molecule natural p...
ORGANISM(S): Homo sapiens (Human) 
2024-04-26 | PXD051762 | Pride
14-3-3 Cysteine Targeted protein localization Covalent Molecular glues 
UnknownMolecular Glues: The Adhesive Connecting Targeted Protein Degradation to the Clinic.
Not available
S-EPMC9910052 | biostudies-literature
UnknownMimicry of molecular glues using dual covalent chimeras.
Not available
S-EPMC11933337 | biostudies-literature
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