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MetabolomicsAntibacterial Monoclonal Antibodies Do Not Disrupt the Intestinal Microbiome or Its Function
Antibiotics revolutionized medicine, however, it is now clear that broad-spectrum antibiotics alter the composition and function of the host’s microbiome. The microbiome plays a key role in human health and its perturbation is increasingly recognized as contributing to many human diseases. Wide spre...
2021-01-11 | MTBLS1257 | MetaboLights
ProteomicsMulti-omics analysis of Histoplasma capsulatum treated with monoclonal antibodies
Multi-omics analysis of Histoplasma capsulatum treated with monoclonal antibodies.
ORGANISM(S): Histoplasma capsulatum G217B 
2021-06-16 | PXD017864 | Pride
Lipid metabolism Histoplasma capsulatum Monoclonal antibodies Multi-omics Fungi Antifungal 
ProteomicsGeneration and utilization of a monoclonal antibody against hepatitis B virus core protein for a comprehensive interactome analysis
Hepatitis B virus (HBV) core antigen (HBc) is a structural protein that forms the viral nucleocapsid and is involved in various steps of the viral replication cycle, but its role in the pathogenesis of HBV infection is still elusive. In this study, we generated a mouse monoclonal antibody against HB...
ORGANISM(S): Homo Sapiens (human) 
2023-02-21 | PXD036961 | JPOST Repository
TranscriptomicsTargetting CD24 for treatment of colorectal and pancreatic cancer by monoclonal antibodies or siRNA
CD24 is a potential oncogene reported to be overexpressed in a large variety of human malignancies. We have shown that CD24 is overexpressed in 90% of colorectal tumors at a fairly early stage in the multistep process of carcinogenesis. Anti-CD24 monoclonal antibodies (mAb) induce a significant grow...
ORGANISM(S): Homo sapiens 
2009-03-07 | E-GEOD-15102 | biostudies-arrayexpress
ProteomicsInfection of RAW 264.7 cells by Murine Leukemia Virus-derived retroviral pseudotype expressing the envelope glycoprotein of EBOV is enhanced by immune serum and monoclonal antibodies
It has been shown that antibodies can enhance Ebola virus (EBOV) infection at sub-neutralizing concentrations. The effect of antibodies on the infection of murine cell line (RAW 264.7) with MLV-EBOV, a murine leukemia virus pseudotype expressing surface glycoprotein (GP) of EBOV and green fluorescen...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2026-01-26 | PXD066513 | Pride
Virus Monoclonal antibodies Proteomic Ebola Epitope 
ProteomicsGluten-specific antibodies of celiac disease gut plasma cells recognize long proteolytic fragments that typically harbor T-cell epitopes
This study aimed to identify proteolytic fragments of gluten proteins recognized by recombinant IgG1 monoclonal antibodies generated from single IgA plasma cells of celiac disease lesions. Peptides bound by monoclonal antibodies in complex gut-enzyme digests of gluten treated with the deamidating en...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080779 | MassIVE
ProteomicsIdentification of HSP70 family proteins as targets of anti-melanosome monoclonal antibodies by immunoprecipitation and LC–MS/MS
This dataset contains proteomic analyses performed to identify the molecular targets of three anti-melanosome monoclonal antibodies (mAbs): Mel321-31, Mel322-34, and Mel321-35. These antibodies were generated following immunization of mice with purified melanosomes and were shown to bind melanosomes...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-23 | PXD074667 | Pride
ProteomicsPathogenic Natural Antibodies Recognizing Annexin IV Are Required to Develop Intestinal Ischemia-Reperfusion Injury
Intestinal ischemia-reperfusion (IR) injury is initiated when natural IgM antibodies recognize neo-epitopes that are revealed on ischemic cells. The target molecules and mechanisms whereby these neo-epitopes become accessible to recognition are not well understood. Proposing that isolated intestinal...
ORGANISM(S): Mus musculus 
2010-05-05 | E-GEOD-14862 | biostudies-arrayexpress
ModelsSumana2018 - Mathematical modeling of cancer-immune system, considering the role of antibodies.
Mathematical modeling of cancer-immune system, considering the role of antibodies. Ghosh S1, Banerjee S2. Author information 1 Department of Mathematics, Indian Institute of Technology Roorkee, Roorkee, Uttaranchal, 247667, India. 2 Department of Mathematics, Indian Institute of Technology ...
2024-09-02 | BIOMD0000000885 | BioModels
Immuno-oncology 
ProteomicsGluten-specific antibodies of celiac disease gut plasma cells recognize long proteolytic fragments that typically harbor T-cell epitopes
This study aimed to identify proteolytic fragments of gluten proteins recognized by recombinant IgG1 monoclonal antibodies generated from single IgA plasma cells of celiac disease lesions. Peptides bound by monoclonal antibodies in complex gut-enzyme digests of gluten treated with the deamidating en...
ORGANISM(S): Homo sapiens (Human) 
2016-05-10 | PXD002678 | Pride
Lc-msms Celiac disease Gliadin Monoclonal antibodies Epitopes 
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