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MetabolomicsAntibacterial Monoclonal Antibodies Do Not Disrupt the Intestinal Microbiome or Its Function
Antibiotics revolutionized medicine, however, it is now clear that broad-spectrum antibiotics alter the composition and function of the host’s microbiome. The microbiome plays a key role in human health and its perturbation is increasingly recognized as contributing to many human diseases. Wide spre...
2021-01-11 | MTBLS1257 | MetaboLights
ProteomicsGeneration and utilization of a monoclonal antibody against hepatitis B virus core protein for a comprehensive interactome analysis
Hepatitis B virus (HBV) core antigen (HBc) is a structural protein that forms the viral nucleocapsid and is involved in various steps of the viral replication cycle, but its role in the pathogenesis of HBV infection is still elusive. In this study, we generated a mouse monoclonal antibody against HB...
ORGANISM(S): Homo Sapiens (human) 
2023-02-21 | PXD036961 | JPOST Repository
ProteomicsAn improved capillary isoelectric focusing-mass spectrometry method for characterization of monoclonal antibody charge variants
Here, we improved the stability and enhanced separation resolution of automated cIEF-MS by bettering the quality of capillary neutral coating, reducing catholyte pH to 10 for cIEF-MS for the first time, and systematically optimizing the cIEF separation conditions for characterization of monoclonal a...
ORGANISM(S): Homo sapiens (Human) 
2026-08-19 | PXD082799 | Pride
Monoclonal antibody charge variants Cief-ms 
ProteomicsEvaluation of Ca37 monoclonal antibody against pathogenic fungal Candidozyma auris
Candidozyma auris, previously known as Candida auris, is a recently found pathogenic yeast that causes systemic infections, showing a high mortality rate. Moreover, this species is highly resistant to the commonly used antifungal drugs and some of the strains are multiresistant. This fungus is also ...
ORGANISM(S): [Candida] auris 
2026-01-05 | PXD070229 | Pride
Fungi Candidozyma auris Alcohol deshydrogenase Monoclonal antibody 
ProteomicsA TCR blocking HLA-A*11:01-specific human monoclonal antibody
Cross-linking mass spectrometry and Targeted cross-linking mass spectrometry for a TCR blocking human monoclonal antibody targeting HLA-A*11:01
ORGANISM(S): Homo Sapiens (human) 
2025-06-02 | PXD053836 | JPOST Repository
ProteomicsHDX-MS implicates dynamic CD20 antigen binding to two discontinuous CDR regions in the NCD1.2 monoclonal antibody
A comparative canine-human therapeutics model is being developed in B-cell lymphoma through the generation of a hybridoma cell that produces a murine monoclonal antibody specific for canine CD20. The hybridoma cell produces two light chains, light chain-3 and light chain-7. However, the contribution...
ORGANISM(S): Canis lupus x Canis lupus familiaris 
2021-09-09 | PXD018550 | Pride
Human Comparative medicine Lymphoma Monoclonal antibody Hdx Adept Phage display Cd20 
TranscriptomicsTranscription profiling by array of human SK-N-AS neuroblastoma xenograft tumor treated with anti-human IGF-IR monoclonal antibody (h10H5) to study the anti-tumour function of the antibody
The insulin-like growth factor (IGF) system consists of two ligands (IGF-I and IGF-II), which both signal through type I IGF receptor (IGF-IR) to stimulate proliferation and inhibit apoptosis, with activity contributing to malignant growth of many types of human cancers. We have developed a humanize...
ORGANISM(S): Homo sapiens 
2008-10-25 | E-GEOD-11959 | biostudies-arrayexpress
ProteomicsHydrogen Deuterium Exchange Mass Spectrometry implicates dynamic CD20 antigen binding to two discontinuous CDR regions in the NCD1.2 monoclonal antibody
A comparative canine-human therapeutics model is being developed in B-cell lymphoma through the generation of a hybridoma cell that produces a murine monoclonal antibody specific for canine CD20. The hybridoma cell produces two light chains, light chain-3 and light chain-7. However, the contribution...
ORGANISM(S): Canis lupus x Canis lupus familiaris 
2021-09-09 | PXD018510 | Pride
Human Comparative medicine Lymphoma Monoclonal antibody Hdx Adept Phage display Cd20 Lc-ms/ms 
UnknownA Review of Anti-Angiogenic Targets for Monoclonal Antibody Cancer Therapy.
Not available
S-EPMC5578174 | biostudies-literature
ProteomicsEpitope fine mapping by mass spectrometry: Investigations of immune complexes consisting of monoclonal anti-HpTGEKP antibody and zinc finger protein linker phospho-hexapeptides.
We describe the mass spectrometric analysis of the binding strength of a monoclonal mouse antibody (clone 18E9.D9, BioLegend, London, England) which was raised against the predominantly occuring phosphorylated linker sequence, HpTGEKP, of C2H2 zinc finger proteins (ZNF proteins) using a synthetic ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-15 | PXD031150 | Pride
Item-two Off-line esi-ms Zinc finger-phosphopeptide Antiphosphopeptide-antibody Binding strength characterization 
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