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ProteomicsDrug Affinity Responsive Target Stability unveils Filamins as biological targets for Artemetin, an anti-cancer flavonoid.
Artemetin is a valuable 5-hydroxy-3,6,7,3',4'-pentamethoxyflavone found in many different medicinal plants with a very good oral bioavailability and drug-likeness values endowed with numerous bioactivities such as anti-inflammatory and anti-cancer ones. Here, a multi-disciplinary strategy has been d...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD034776 | Pride
Anti-cancer. Bioactive natural compounds Drug affinity responsive target stability Cytoskeleton Proteomics 
ProteomicsArzanol Biomolecular Targets - Chemoproteomic fishing identifies arzanol as a positive modulator of brain glycogen phosphorylase
The interactome of arzanol was investigated by MS-based chemical proteomics, a pioneering technology for small molecules target discovery. Brain glycogen phosphorylase (bGP), a key regulator of glucose metabolism so far refractory to small molecule modulation, was identified as the main high-affinit...
ORGANISM(S): Homo sapiens (Human) 
2019-03-25 | PXD011170 | Pride
Arzanol Chemical proteomics Brain glycogen phosphorylase 
ProteomicsLLS7(P)-M-NPs Protein Corona Characterization
Characterization of LLS7(P)-M-NPs protein corona in SWF (Simulated Wound Fluid) matrix.
ORGANISM(S): Bos taurus (Bovine) 
2025-10-26 | PXD058949 | Pride
Protein corona Nanoparticles Simulated wound fluid 
UnknownMolecular allergens drive risk stratification and immunotherapy in Hymenoptera venom allergy.
Not available
S-EPMC12546951 | biostudies-literature
ProteomicsNew label free methods for protein relative quantification applied to the investigation of animal model of Huntington Disease.
Spectral Counts approaches (SpCs) are largely employed for the comparison of protein expression profiles in label free differential proteomics applications. Similarly, to other comparative methods, also SpCs based approaches require a normalization procedure before Fold Changes (FC) calculation. Her...
ORGANISM(S): Mus musculus (Mouse) 
2020-08-18 | PXD017471 | Pride
Label free methods  spectral counts normalization  complexity-based correction factor  huntington disease mice models 
ProteomicsProteomic and degradomic signatures of extracellular matrix remodeling in calcific aortic valve
Calcific aortic valve disease (CAVD) is the most common valvular heart disease in older adults, but no medical therapy is currently able to halt or reverse its progression, partly because the molecular mechanisms of valve remodeling remain incompletely understood. Here, we aimed to dissect the extra...
ORGANISM(S): Homo sapiens (Human) 
2026-05-29 | PXD073246 | Pride
Aortic valve stenosis Extracellular matrix remodeling proteomics Calcific aortic valve disease Collagen post-translational modifications 
ProteomicsProteomic and degradomic signatures of extracellular matrix remodeling in calcific aortic valve stenotic
Calcific aortic valve disease (CAVD) is the most common valvular heart disease in older adults, but no medical therapy is currently able to halt or reverse its progression, partly because the molecular mechanisms of valve remodeling remain incompletely understood. Here, we aimed to dissect the extra...
ORGANISM(S): Homo sapiens (Human) 
2026-05-29 | PXD070758 | Pride
Calcific aortic valve disease Collagen post-translational modifications Aortic valve stenosis Extracellular matrix remodeling proteomics 
ProteomicsCombining proteomics and machine learning to identify triple negative breast cancer biomarkers binding telomeric G-Quadruplex
Triple-negative breast cancer (TNBC) lacks ER, PR and HER2 expression, represents ~10–20% of invasive breast cancers, and is clinically aggressive with limited targeted treatment options. Its pronounced molecular heterogeneity challenges single-marker diagnostics, motivating the development of robus...
ORGANISM(S): Homo sapiens (Human) 
2026-05-29 | PXD072964 | Pride
Tel46 Tnbc Gquadruplex Cancer Breast Dna Quantitative proteomics Biomarkes 
MetabolomicsSelective profiling of translationally active tRNAs and their dynamics under stress

During translation, transfer RNAs (tRNAs) deliver specific amino acids to the ribosome in a coordinated manner with the sequence encoded by the mRNA. Despite their central role in protein synthesis, the precise contribution of tRNAs to the modulation of translation remains poorly understood, prim...

2026-06-25 | MTBLS12806 | MetaboLights
ProteomicsSpike S1 domain interactome in non-pulmonary systems: a role beyond the receptor recognition
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes Coronavirus Disease 2019 (COVID-19), which, since 2019 in China, has rapidly become a worldwide pandemic. The aggressiveness and global spread were enhanced by the many SARS-CoV-2 variants that have been isolated up to now. These mu...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD035709 | Pride
Ap-ms Sars-cov-2 Proteomics S1 domain Interactomics Host-virus interaction Covid-19 Spike protein 
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